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EnglishThe B203.13 monoclonal antibody was developed by immunizing mice with the B/monocyte biphenotypic cell line B1b. During normal hematopoiesis B203.13 is expressed on a fraction of CD34+ cells, while on mature cells it is only present on B-lymphocytes. We tested this antibody as a marker of childhood B-acute lymphoblastic leukemia (B-ALL). Bone marrow aspirates from 139 cases of early B-ALL and 25 controls were studied. About 40% of the B-ALL patients expressed B203.13. In these patients, B203.13 was constantly co-expressed with CD10, but never co-expressed with CD20, contrary to the controls. The CD10(+)/B203.13(+) phenotype was specific to B-ALL, since CD10(+)/CD20(+) cells from common acute lymphoblastic leukemia (c-ALL) did not express B203.13. We concluded that the use of B203.13 in association with CD10 and CD20 provides meaningful information for distinguishing normal residual B-cells from leukemic B-lymphoblasts and that recurrence of a CD10(+)/B203.13(+) phenotype after transplantation may be a very early relapse indicator of early B-acute lymphoblastic leukemia.
Gobbi, G., Mirandola, P., Malinverno, C., Sponzilli, I., Carubbi, C., Ricci, F., et al. (2008). Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin. INTERNATIONAL JOURNAL OF ONCOLOGY, 33, 2-371.
| Tipologia: | Articolo su rivista |
| Citazione: | Gobbi, G., Mirandola, P., Malinverno, C., Sponzilli, I., Carubbi, C., Ricci, F., et al. (2008). Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin. INTERNATIONAL JOURNAL OF ONCOLOGY, 33, 2-371. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/28 - Malattie Odontostomatologiche |
| Revisione (peer review): | Esperti anonimi |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3892/ijo_00000017 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2-ago-2008 |
| Titolo: | Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin. |
| Autori: | |
| Autori: | Gobbi, G; Mirandola, P; Malinverno, C; Sponzilli, I; Carubbi, C; Ricci, F; Binazzi, R; Basso, G; Giuliani-Piccari, G; Ramazzotti, G; Pasquantonio, G; Cocco, L; Vitale, M |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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