Background: Immune system plays a crucial role in defending organism from pathogens. However, immunological functions may be severely impaired by a number of disorders including acquired immunodeficiencies, possibly due to infections, chronic diseases, immunosuppressive drugs or surgeon therapies. In order to favour the immune reconstitution of patients with acquired immunodeficiency, various therapeutic treatments are constantly under investigation for both adults and paediatric patients. Aim of the study: To evaluate immune reconstitution in children with acquired immunodeficiency. Attention was focused on two groups of HIV-1 vertically infected children (the first group subjected to HAART from the third months of life, the second subjected to a simplified treatment) and on a cohort of leukaemia children who underwent Umbilical Cord Blood Transplantation (UCBT). Materials and Methods: Immune restoration was principally evaluated in terms of lymphoproliferative response and T-cell receptor (TCR) repertoire. Immunological studies were complemented by routine clinical and laboratory analyses. Results: HIV-infected children showed a significant normalization of immune functions investigated, with a long-term maintaining of good clinical and immunological parameters. Also children who underwent UCBT showed a notable immune restoration. Conclusions: In HIV-infected children, an early application of antiretroviral treatment from the third month of life favours immune reconstitution and the application of a simplified regimen seems to permit the maintenance of good immunological results obtained during the previous successful HAART. In the context of transplanted children our data underline applicability and advantages of UBCT compared to Bone marrow (BM) transplantations.
Pensieroso, S. (2008). Immune reconstitution in paediatric patients with acquired immunodeficiency.
|Titolo:||Immune reconstitution in paediatric patients with acquired immunodeficiency|
|Data di pubblicazione:||2-set-2008|
|Anno Accademico:||A.A. 2006/2007|
|Corso di dottorato:||Immunologia|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/38 - Pediatria Generale e Specialistica
|Tipologia:||Tesi di dottorato|
|Citazione:||Pensieroso, S. (2008). Immune reconstitution in paediatric patients with acquired immunodeficiency.|
|Appare nelle tipologie:||07 - Tesi di dottorato|