Preterm newborns represent a high-risk population for brain damage, primarily affecting the white matter, and for related neurodevelopmental disabilities. Determinants of brain damage have been extensively investigated, but there are still many controversies on how these factors can influence the developing brain and provoke damage. The concept of etiological pathway, instead of a single determinant, appears to better explain pathogenetic mechanisms: the brain damage may represent the final outcome of exposure to several combinations of risk factors in the same pathway or in different pathways and can change according to the gestational age. The aim of this article is to review the current knowledge on the pathogenesis of brain damage in preterm infants, within the frame of two main theoretical models, the ischemic and the inflammatory pathway. The relationship between the two pathways and the contribution of genetic susceptibility to ischemic and/or inflammatory insult, in modulating the extent and severity of brain damage, is also discussed.

Arpino, C., D'Argenzio, L., Ticconi, C., DI PAOLO, A., Stellin, V., Lopez, L., et al. (2004). Brain damage in preterm infants: etiological pathways, 41(2), 229.

Brain damage in preterm infants: etiological pathways

ARPINO, CARLA;TICCONI, CARLO;DI PAOLO, AMBROGIO;CURATOLO, PAOLO
2004-04-01

Abstract

Preterm newborns represent a high-risk population for brain damage, primarily affecting the white matter, and for related neurodevelopmental disabilities. Determinants of brain damage have been extensively investigated, but there are still many controversies on how these factors can influence the developing brain and provoke damage. The concept of etiological pathway, instead of a single determinant, appears to better explain pathogenetic mechanisms: the brain damage may represent the final outcome of exposure to several combinations of risk factors in the same pathway or in different pathways and can change according to the gestational age. The aim of this article is to review the current knowledge on the pathogenesis of brain damage in preterm infants, within the frame of two main theoretical models, the ischemic and the inflammatory pathway. The relationship between the two pathways and the contribution of genetic susceptibility to ischemic and/or inflammatory insult, in modulating the extent and severity of brain damage, is also discussed.
apr-2004
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Settore MED/39 - NEUROPSICHIATRIA INFANTILE
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Senza Impact Factor ISI
Brain damage; Genetic susceptibility; Hypoxia; Inflammation; Ischemia; Preterm
Arpino, C., D'Argenzio, L., Ticconi, C., DI PAOLO, A., Stellin, V., Lopez, L., et al. (2004). Brain damage in preterm infants: etiological pathways, 41(2), 229.
Arpino, C; D'Argenzio, L; Ticconi, C; DI PAOLO, A; Stellin, V; Lopez, L; Curatolo, P
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/60731
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 39
  • ???jsp.display-item.citation.isi??? ND
social impact