To test the hypothesis that fluoxetine may be a useful adjunct to antiepileptic therapy, we treated with fluoxetine (20-40 mg/day) nine patients suffering from medically intractable epilepsy with daily seizures. Five patients remained unchanged and four worsened. Worsening was more evident at 40 mg/day. One patient improved when receiving the lower dose (20 mg/day) and worsened with the higher dose (40 mg/day). These data suggest: (1) that fluoxetine is not effective as add-on antiepileptic treatment; (2) that caution should be exerted when using fluoxetine as an antidepressive treatment in epileptic patients.
Gigli, G., Diomedi, M., Troisi, A., Baldinetti, F., Marciani, M.g., Girolami, E., et al. (1994). Lack of potentiation of anticonvulsant effect by fluoxetine in drug-resistant epilepsy. SEIZURE, 3(3), 221-224.
Lack of potentiation of anticonvulsant effect by fluoxetine in drug-resistant epilepsy
DIOMEDI, MARINA;TROISI, ALFONSO;MARCIANI, MARIA GRAZIA;PASINI, AUGUSTO
1994-09-01
Abstract
To test the hypothesis that fluoxetine may be a useful adjunct to antiepileptic therapy, we treated with fluoxetine (20-40 mg/day) nine patients suffering from medically intractable epilepsy with daily seizures. Five patients remained unchanged and four worsened. Worsening was more evident at 40 mg/day. One patient improved when receiving the lower dose (20 mg/day) and worsened with the higher dose (40 mg/day). These data suggest: (1) that fluoxetine is not effective as add-on antiepileptic treatment; (2) that caution should be exerted when using fluoxetine as an antidepressive treatment in epileptic patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
