Purpose. To explore the expression of fatty acid synthase (FAS) and human erythrocyte glucose transporter 1 (GLUT1) in endometrial carcinomas and to detect associations with clinicopathological features and prognosis. FAS and GLUT1 are two molecules involved in energy supply of normal cells. These markers are overexpressed in neoplastic tissues because of their increased necessity of energy. Methods. Ninety-five patients with endometrial carcinoma were followed-up for an average period of 5 years. FAS and GLUT1 expressions were evaluated by immunohistochemistry on formalin-fixed paraffin-embedded tissues. Staining was determined with a semiquantitative method. Negative controls were obtained from patients submitted to hysterectomy for uterine prolapse. Results. Eighty-five cases were endometrioid, 7 were serous, and 1 was a mucinous carcinoma. Seventy-two cases (75%) were stage I, 12 (13%) were stage II, and 11 (12%) were stage III carcinomas. Sixteen (15%) carcinomas recurred. Nine patients (8%) died for cancer during the follow-up period. FAS expression was observed in 53 cases (56%). GLUT1 expression was observed in 32 (43%) cases. Statistical analysis revealed that FAS (P = 0.04) and stage (P = 0.001) of the disease were the only two independent predictors of recurrence. GLUT1 and other clinicopathologic parameters had no prognostic association. Conclusions. FAS is a reliable marker of clinically aggressive endometrial carcinomas. The knowledge of FAS expression in endometrial carcinomas is an important finding that may stratify patients into selected groups and determine therapeutic approaches for patient care. © 2003 Elsevier Inc. All rights reserved.

Sebastiani, V., Visca, P., Botti, C., SANTEUSANIO, G., Galati, G.M., Piccini, V., et al. (2004). Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma. GYNECOLOGIC ONCOLOGY REPORT, 92(1), 101-105 [10.1016/j.ygyno.2003.10.027].

Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma

SANTEUSANIO, GIUSEPPE;
2004

Abstract

Purpose. To explore the expression of fatty acid synthase (FAS) and human erythrocyte glucose transporter 1 (GLUT1) in endometrial carcinomas and to detect associations with clinicopathological features and prognosis. FAS and GLUT1 are two molecules involved in energy supply of normal cells. These markers are overexpressed in neoplastic tissues because of their increased necessity of energy. Methods. Ninety-five patients with endometrial carcinoma were followed-up for an average period of 5 years. FAS and GLUT1 expressions were evaluated by immunohistochemistry on formalin-fixed paraffin-embedded tissues. Staining was determined with a semiquantitative method. Negative controls were obtained from patients submitted to hysterectomy for uterine prolapse. Results. Eighty-five cases were endometrioid, 7 were serous, and 1 was a mucinous carcinoma. Seventy-two cases (75%) were stage I, 12 (13%) were stage II, and 11 (12%) were stage III carcinomas. Sixteen (15%) carcinomas recurred. Nine patients (8%) died for cancer during the follow-up period. FAS expression was observed in 53 cases (56%). GLUT1 expression was observed in 32 (43%) cases. Statistical analysis revealed that FAS (P = 0.04) and stage (P = 0.001) of the disease were the only two independent predictors of recurrence. GLUT1 and other clinicopathologic parameters had no prognostic association. Conclusions. FAS is a reliable marker of clinically aggressive endometrial carcinomas. The knowledge of FAS expression in endometrial carcinomas is an important finding that may stratify patients into selected groups and determine therapeutic approaches for patient care. © 2003 Elsevier Inc. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - Anatomia Patologica
English
Con Impact Factor ISI
Carcinoma; Endometrial; Fatty acid synthase; Prognosis
fatty acid synthase; formaldehyde; glucose transporter; glucose transporter 1; GLUT 1 protein; GLUT-1 protein; paraffin; tumor marker; adult; article; biosynthesis; cancer mortality; cancer patient; cancer recurrence; cancer risk; cancer staging; clinical feature; controlled study; endometrioid carcinoma; endometrium carcinoma; endometrium tumor; energy resource; enzymology; female; follow up; gene overexpression; histopathology; human; human tissue; hysterectomy; immunohistochemistry; major clinical study; metabolism; mucinous carcinoma; pathology; priority journal; prognosis; protein expression; statistical analysis; statistical significance; treatment outcome; tumor recurrence; uterus prolapse; Endometrial Neoplasms; Fatty Acid Synthetase Complex; Female; Follow-Up Studies; Glucose Transporter Type 1; Humans; Immunohistochemistry; Middle Aged; Monosaccharide Transport Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Tumor Markers, Biological
Sebastiani, V., Visca, P., Botti, C., SANTEUSANIO, G., Galati, G.M., Piccini, V., et al. (2004). Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma. GYNECOLOGIC ONCOLOGY REPORT, 92(1), 101-105 [10.1016/j.ygyno.2003.10.027].
Sebastiani, V; Visca, P; Botti, C; Santeusanio, G; Galati, Gm; Piccini, V; De Joannon, Bc; Di Tondo, U; Alo, Pl
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/58603
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