Background: The prevalence of the Brugada-type ECG and its natural history are still unclear. The recently proposed diagnostic criteria have not been systematically applied in a European general population. Methods: We retrospectively analyzed ECGs and clinical data of 12,012 apparently healthy individuals who had undergone medical examination for occupational reasons. We sought follow-up information on the subjects with at least one ECG fulfilling the criteria for the Brugada pattern. Results: A Brugada-type ECG was found in 23 subjects (0.19%; 95% confidence interval 0.12-0.27%) on the first ECG recorded in that subject. In a further 8 cases, the Brugada pattern was present in a subsequent ECG, so that it was present at some time in 31 subjects (0.26%, 95% confidence interval 0.18-0.37%), all male. Only 2 patients displayed the classical type 1 Brugada ECG pattern. In 29 patients (94%), clinical information was available subsequent to the first Brugada pattern ECG recorded. The mean follow-up was 10.1 +/- 5.5 years. A sudden death occurred in a 27-year-old man with Brugada type 2 ECG pattern. No sudden death or symptomatic ventricular arrhythmia occurred among the other 28 patients. The annual rate of sudden death associated with Brugada ECG pattern was 0.3% per patient-year of follow-up. Conclusion: The Brugada-type ECG pattern, as currently defined, is uncommon in a young healthy male European population and confers a moderately elevated risk of sudden death. Our findings underscore the need to study risk predictors in asymptomatic patients with a Brugada-type ECG. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

Gallagher, M.m., Forleo, G.b., Behr, E.r., Magliano, G., De Luca, L., Morgia, V., et al. (2008). Prevalence and significance of Brugada-type ECG in 12,012 apparently healthy European subjects. INTERNATIONAL JOURNAL OF CARDIOLOGY, 130(1), 44-48 [10.1016/j.ijcard.2007.07.159].

Prevalence and significance of Brugada-type ECG in 12,012 apparently healthy European subjects

ROMEO, FRANCESCO
2008-01-01

Abstract

Background: The prevalence of the Brugada-type ECG and its natural history are still unclear. The recently proposed diagnostic criteria have not been systematically applied in a European general population. Methods: We retrospectively analyzed ECGs and clinical data of 12,012 apparently healthy individuals who had undergone medical examination for occupational reasons. We sought follow-up information on the subjects with at least one ECG fulfilling the criteria for the Brugada pattern. Results: A Brugada-type ECG was found in 23 subjects (0.19%; 95% confidence interval 0.12-0.27%) on the first ECG recorded in that subject. In a further 8 cases, the Brugada pattern was present in a subsequent ECG, so that it was present at some time in 31 subjects (0.26%, 95% confidence interval 0.18-0.37%), all male. Only 2 patients displayed the classical type 1 Brugada ECG pattern. In 29 patients (94%), clinical information was available subsequent to the first Brugada pattern ECG recorded. The mean follow-up was 10.1 +/- 5.5 years. A sudden death occurred in a 27-year-old man with Brugada type 2 ECG pattern. No sudden death or symptomatic ventricular arrhythmia occurred among the other 28 patients. The annual rate of sudden death associated with Brugada ECG pattern was 0.3% per patient-year of follow-up. Conclusion: The Brugada-type ECG pattern, as currently defined, is uncommon in a young healthy male European population and confers a moderately elevated risk of sudden death. Our findings underscore the need to study risk predictors in asymptomatic patients with a Brugada-type ECG. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
English
Brugada syndrome; Epidemiology; Idiopathic ventricular fibrillation; Risk stratification; Sudden death
adult; article; Brugada syndrome; controlled study; electrocardiogram; Europe; heart ventricle arrhythmia; high risk patient; human; major clinical study; male; prevalence; priority journal; risk factor; sudden death; Brugada Syndrome; Electrocardiography; Europe; Humans; Prevalence
Gallagher, M.m., Forleo, G.b., Behr, E.r., Magliano, G., De Luca, L., Morgia, V., et al. (2008). Prevalence and significance of Brugada-type ECG in 12,012 apparently healthy European subjects. INTERNATIONAL JOURNAL OF CARDIOLOGY, 130(1), 44-48 [10.1016/j.ijcard.2007.07.159].
Gallagher, Mm; Forleo, Gb; Behr, Er; Magliano, G; De Luca, L; Morgia, V; De Liberato, F; Romeo, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/57771
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