The formation of trans FA residues in membrane phospholipids may be due to a free radical-catalyzed isomerization process occurring to the cis unsaturated FA moieties. Radical stress is well documented in inflammatory processes of atopic diseases, but no data are yet available about a possible association with trans FA detected in these patients. We investigated the presence of trans lipid isomers in the erythrocyte and T-lymphocyte membranes of 26 children affected by atopic eczema/dermatitis syndrome (AEDS). Trans lipid isomers were found in both cell membranes, up to a total content of 2.7 and 4.9% of the FA composition, respectively. By using the geometrical trans lipid library derived from in vitro models of thiyl radical-catalyzed isomerization, oleic and arachidonic acid isomers were detected. The statistical significance was evaluated by comparison with an age-matched control group. These results suggest the role of an endogenous free radical isomerization path occurring to membrane unsaturated lipids, complementary to the dietary contribution, which can be involved in the lipid impairment in AEDS. This study contributes to lipidomic research regarding the double bond structure and the influence of a geometrical change of membrane lipids in physiology and diseases.

Ferreri C., Angelini F., Chatgilialoglu C., Dellonte S., Moschese V., Rossi P., et al. (2005). Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis-trans isomerization of membrane lipids. LIPIDS, 40(7), 661-667 [10.1007/s11745-005-1428-7].

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis-trans isomerization of membrane lipids

ANGELINI, FEDERICA;MOSCHESE, VIVIANA;ROSSI, PAOLO;CHINI, LOREDANA
2005-07

Abstract

The formation of trans FA residues in membrane phospholipids may be due to a free radical-catalyzed isomerization process occurring to the cis unsaturated FA moieties. Radical stress is well documented in inflammatory processes of atopic diseases, but no data are yet available about a possible association with trans FA detected in these patients. We investigated the presence of trans lipid isomers in the erythrocyte and T-lymphocyte membranes of 26 children affected by atopic eczema/dermatitis syndrome (AEDS). Trans lipid isomers were found in both cell membranes, up to a total content of 2.7 and 4.9% of the FA composition, respectively. By using the geometrical trans lipid library derived from in vitro models of thiyl radical-catalyzed isomerization, oleic and arachidonic acid isomers were detected. The statistical significance was evaluated by comparison with an age-matched control group. These results suggest the role of an endogenous free radical isomerization path occurring to membrane unsaturated lipids, complementary to the dietary contribution, which can be involved in the lipid impairment in AEDS. This study contributes to lipidomic research regarding the double bond structure and the influence of a geometrical change of membrane lipids in physiology and diseases.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - Pediatria Generale e Specialistica
English
Con Impact Factor ISI
Cell membranes; Chemical bonds; Data acquisition; Free radicals; Isomerization; Isomers; Phospholipids; Arachidonic acid isomers; Atopic eczema/dermatitis syndrome (AEDS); Lipodomic research; Membrane lipids; Fatty acids; arachidonic acid derivative; free radical; immunoglobulin E; membrane phospholipid; monounsaturated fatty acid; saturated fatty acid; trans fatty acid; article; atopic dermatitis; B lymphocyte; blood sampling; child; clinical article; controlled study; dermatitis; eczema; erythrocyte membrane; fatty acid analysis; female; gas chromatography; geometry; human; human cell; infant; isomerization; lipid analysis; male; monocyte; peripheral blood mononuclear cell; T lymphocyte; Chromatography, Gas; Dermatitis, Atopic; Fatty Acids; Free Radicals; Humans; Isomerism; Membrane Lipids
Ferreri C., Angelini F., Chatgilialoglu C., Dellonte S., Moschese V., Rossi P., et al. (2005). Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis-trans isomerization of membrane lipids. LIPIDS, 40(7), 661-667 [10.1007/s11745-005-1428-7].
Ferreri, C; Angelini, F; Chatgilialoglu, C; Dellonte, S; Moschese, V; Rossi, P; Chini, L
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/57266
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact