We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
Brodeur, S.r., Angelini, F., Bacharier, L.b., Blom, A.m., Mizoguchi, E., Fujiwara, H., et al. (2003). C4b-binding protein (C4BP) activates B cells through the CD40 receptor. IMMUNITY, 18(6), 837-848 [10.1016/S1074-7613(03)00149-3].
C4b-binding protein (C4BP) activates B cells through the CD40 receptor
ANGELINI, FEDERICA;
2003-06-01
Abstract
We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.| Campo DC | Valore | Lingua |
|---|---|---|
| dc.authority.academicField2000 | Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA | it |
| dc.authority.ancejournal | IMMUNITY | - |
| dc.authority.isicrui | Immunologia | it |
| dc.authority.people | Brodeur S. R. | - |
| dc.authority.people | ANGELINI, FEDERICA | it |
| dc.authority.people | Bacharier L. B. | - |
| dc.authority.people | Blom A. M. | - |
| dc.authority.people | Mizoguchi E. | - |
| dc.authority.people | Fujiwara H. | - |
| dc.authority.people | Plebani A. | - |
| dc.authority.people | Notarangelo L. D. | - |
| dc.authority.people | Dahlback B. | - |
| dc.authority.people | Tsitsikov E. | - |
| dc.authority.people | Geha R. S. | - |
| dc.cilea.antefix | yes | it |
| dc.cilea.autoapproval | Questa scheda non e' stata ancora verificata e potrebbe quindi contenere imprecisioni. Scheda pubblicata automaticamente il Thu Mar 15 18:45:20 CET 2012 | - |
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| dc.collection.name | 01 - Articolo su rivista | * |
| dc.contributor.appartenenza | Dipartimento di Medicina dei sistemi | * |
| dc.contributor.appartenenza.mi | 7081 | * |
| dc.contributor.area | AREA MIN. 06 - Scienze mediche | * |
| dc.date.accessioned | 2012/03/15 18:45:21 | - |
| dc.date.available | 2012/03/15 18:45:21 | - |
| dc.date.issued | 2003-06 | - |
| dc.description.abstracteng | We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation. | - |
| dc.description.allpeople | Brodeur, Sr; Angelini, F; Bacharier, Lb; Blom, Am; Mizoguchi, E; Fujiwara, H; Plebani, A; Notarangelo, Ld; Dahlback, B; Tsitsikov, E; Geha, Rs | - |
| dc.description.allpeopleoriginal | Brodeur S.R., Angelini F., Bacharier L.B., Blom A.M., Mizoguchi E., Fujiwara H., Plebani A., Notarangelo L.D., Dahlback B., Tsitsikov E., Geha R.S. | it |
| dc.description.fulltext | none | en |
| dc.description.numberofauthors | 11 | - |
| dc.identifier.citation | Brodeur, S.r., Angelini, F., Bacharier, L.b., Blom, A.m., Mizoguchi, E., Fujiwara, H., et al. (2003). C4b-binding protein (C4BP) activates B cells through the CD40 receptor. IMMUNITY, 18(6), 837-848 [10.1016/S1074-7613(03)00149-3]. | it |
| dc.identifier.doi | 10.1016/S1074-7613(03)00149-3 | it |
| dc.identifier.isi | WOS:000183767700013 | - |
| dc.identifier.scopus | 2-s2.0-0038503986 | - |
| dc.identifier.uri | http://hdl.handle.net/2108/57263 | - |
| dc.language.iso | eng | it |
| dc.relation.firstpage | 837 | it |
| dc.relation.issue | 6 | it |
| dc.relation.lastpage | 848 | it |
| dc.relation.volume | 18 | it |
| dc.subject.keywordseng | binding protein; CD40 ligand; CD86 antigen; complement component C4b binding protein; I kappa B kinase; I kappa B kinase gamma; immunoglobulin E; intercellular adhesion molecule 1; interleukin 4; protein; unclassified drug; alpha chain; antigen binding; article; B lymphocyte activation; binding site; cellular distribution; controlled study; human; human cell; human tissue; lymphocyte proliferation; priority journal; protein expression; protein function; protein localization; protein protein interaction; tonsil; upregulation; Antigens, CD; Antigens, CD40; Antigens, Differentiation; B-Lymphocytes; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Complement Inactivator Proteins; Glycoproteins; Humans; Immunoglobulin E; Intercellular Adhesion Molecule-1; Interleukin-4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Tonsil; Up-Regulation | - |
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| dc.subject.singlekeyword | I kappa B kinase | * |
| dc.subject.singlekeyword | I kappa B kinase gamma | * |
| dc.subject.singlekeyword | immunoglobulin E | * |
| dc.subject.singlekeyword | intercellular adhesion molecule 1 | * |
| dc.subject.singlekeyword | interleukin 4 | * |
| dc.subject.singlekeyword | protein | * |
| dc.subject.singlekeyword | unclassified drug | * |
| dc.subject.singlekeyword | alpha chain | * |
| dc.subject.singlekeyword | antigen binding | * |
| dc.subject.singlekeyword | article | * |
| dc.subject.singlekeyword | B lymphocyte activation | * |
| dc.subject.singlekeyword | binding site | * |
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| dc.subject.singlekeyword | B-Lymphocytes | * |
| dc.subject.singlekeyword | Carrier Proteins | * |
| dc.subject.singlekeyword | Cell Adhesion Molecules | * |
| dc.subject.singlekeyword | Cell Division | * |
| dc.subject.singlekeyword | Complement Inactivator Proteins | * |
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| dc.subject.singlekeyword | Humans | * |
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| dc.subject.singlekeyword | p38 Mitogen-Activated Protein Kinases | * |
| dc.subject.singlekeyword | Tonsil | * |
| dc.subject.singlekeyword | Up-Regulation | * |
| dc.title | C4b-binding protein (C4BP) activates B cells through the CD40 receptor | it |
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| Appare nelle tipologie: | 01 - Articolo su rivista | |
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