The enhancer DNase-hypersensitive region 1,2 (HS1,2), a member of the Ig heavy-chain 3' regulatory region (TRR) cluster, is active in human B cells transfected with reporter genes and in mouse is activated in late maturation. HS1,2-A contains binding sites for several transcription factors. There are four known alleles, that is, *1, *2, *3, and *4, which differ in their lengths in transcription factor binding. We showed that in celiac disease the frequency of the *2 allele is increased. Both dermatitis herpetiformis (DH) and psoriasis can be associated with different frequencies with celiac disease. Thus, we further investigate the frequency of allele *2 in DH, plaque psoriatic, and psoriatic arthritis patients. HS1,2-A allele frequencies were investigated in 37 DH, 61 plaque psoriatic, 28 psoriatic arthritis patients, and 265 healthy donors, age- and sex-matched, from the same geographical area. The frequency of the *2 allele changes from 0.39 in controls to 0.63 in DH, 0.59 in plaque psoriasis and 0.75 in psoriatic arthritis (P between 10(-4)-10(-5)). Our data evidence an increased frequency of the *2 allele of HS1,2-A in these cutaneous immune-related disorders. We suggest a related genetic predisposition in these pathogeneses.

Cianci, R., Giambra, V., Mattioli, C., Esposito, M., Cammarota, G., Scibilia, G., et al. (2008). Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(8), 1920-1924 [10.1038/jid.2008.40].

Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis

BIANCHI, LUCA;FREZZA, DOMENICO
2008

Abstract

The enhancer DNase-hypersensitive region 1,2 (HS1,2), a member of the Ig heavy-chain 3' regulatory region (TRR) cluster, is active in human B cells transfected with reporter genes and in mouse is activated in late maturation. HS1,2-A contains binding sites for several transcription factors. There are four known alleles, that is, *1, *2, *3, and *4, which differ in their lengths in transcription factor binding. We showed that in celiac disease the frequency of the *2 allele is increased. Both dermatitis herpetiformis (DH) and psoriasis can be associated with different frequencies with celiac disease. Thus, we further investigate the frequency of allele *2 in DH, plaque psoriatic, and psoriatic arthritis patients. HS1,2-A allele frequencies were investigated in 37 DH, 61 plaque psoriatic, 28 psoriatic arthritis patients, and 265 healthy donors, age- and sex-matched, from the same geographical area. The frequency of the *2 allele changes from 0.39 in controls to 0.63 in DH, 0.59 in plaque psoriasis and 0.75 in psoriatic arthritis (P between 10(-4)-10(-5)). Our data evidence an increased frequency of the *2 allele of HS1,2-A in these cutaneous immune-related disorders. We suggest a related genetic predisposition in these pathogeneses.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/35 - Malattie Cutanee e Veneree
English
Con Impact Factor ISI
adult; article; clinical article; controlled study; dermatitis herpetiformis; female; gene frequency; genetic predisposition; heavy chain; human; male; nucleotide sequence; priority journal; psoriasis vulgaris; psoriatic arthritis; Adult; Alleles; Arthritis, Psoriatic; Base Sequence; Case-Control Studies; Dermatitis Herpetiformis; Enhancer Elements (Genetics); Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Immunoglobulin Heavy Chains; Male; Middle Aged; Molecular Sequence Data; Psoriasis
Cianci, R., Giambra, V., Mattioli, C., Esposito, M., Cammarota, G., Scibilia, G., et al. (2008). Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(8), 1920-1924 [10.1038/jid.2008.40].
Cianci, R; Giambra, V; Mattioli, C; Esposito, M; Cammarota, G; Scibilia, G; Magazzu, G; Orlando, A; Sandri, G; Bianchi, L; Gasbarrini, G; Pandolfi, F; Frezza, D
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/57118
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