Context: Autoantibodies to adenohypophyseal endocrine cells or to vasopressin neurohypophyseal neurons have long been known. Conversely, autoimmune targeting of further hypothalamic-hypophyseal structures, such as the blood-brain barrier-deprived median eminence, has been little studied. Objective and Methods: We studied a case of autoimmune polyendocrine syndrome type I with GH secretory deficiency, a distinctly rare event in autoimmune polyendocrine syndrome type I. We used rat and bovine tissue substrates to study autoantibodies against hypothalamic-hypophyseal nerve structures and endocrine cells. Results: In the study case, circulating autoantibodies selectively decorated median eminence dopaminergic nerve terminals, as well as pituitary gonadotropes, but not GHRH nerve terminals or pituitary somatotropes. Such autoantibodies appeared de novo in parallel with the onset of GH secretory deficiency, whereas no median eminence labeling was found in patients suffering of idiopathic GH deficiency (n = 7) or in healthy controls (n = 23). Conclusions: The pathophysiological significance of our patient's autoantibodies remains to be confirmed. Nonetheless, the heterogeneous neuroendocrine structures of the median eminence are pointed out as potential immune targets, relevant to autoimmune polyendo-crinopathy, as well as to a wide range of other conditions.

Cocco, C., Meloni, A., Boi, F., Pinna, G., Possenti, R., Mariotti, S., et al. (2005). Median eminence dopaminergic nerve terminals: a novel target in autoimmune polyendocrine syndrome?. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 90(7), 4108-4111 [10.1210/jc.2004-2184].

Median eminence dopaminergic nerve terminals: a novel target in autoimmune polyendocrine syndrome?

POSSENTI, ROBERTA;
2005-01-01

Abstract

Context: Autoantibodies to adenohypophyseal endocrine cells or to vasopressin neurohypophyseal neurons have long been known. Conversely, autoimmune targeting of further hypothalamic-hypophyseal structures, such as the blood-brain barrier-deprived median eminence, has been little studied. Objective and Methods: We studied a case of autoimmune polyendocrine syndrome type I with GH secretory deficiency, a distinctly rare event in autoimmune polyendocrine syndrome type I. We used rat and bovine tissue substrates to study autoantibodies against hypothalamic-hypophyseal nerve structures and endocrine cells. Results: In the study case, circulating autoantibodies selectively decorated median eminence dopaminergic nerve terminals, as well as pituitary gonadotropes, but not GHRH nerve terminals or pituitary somatotropes. Such autoantibodies appeared de novo in parallel with the onset of GH secretory deficiency, whereas no median eminence labeling was found in patients suffering of idiopathic GH deficiency (n = 7) or in healthy controls (n = 23). Conclusions: The pathophysiological significance of our patient's autoantibodies remains to be confirmed. Nonetheless, the heterogeneous neuroendocrine structures of the median eminence are pointed out as potential immune targets, relevant to autoimmune polyendo-crinopathy, as well as to a wide range of other conditions.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09
English
Con Impact Factor ISI
autoantibody; growth hormone; growth hormone releasing factor; recombinant growth hormone; adolescent; animal tissue; article; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; case report; child; controlled study; dopaminergic nerve cell; endocrine cell; female; growth hormone deficiency; heterozygosity; hormone release; human; hypothalamus hypophysis system; immunofluorescence; laboratory test; male; median eminence; nerve ending; nonhuman; nuclear magnetic resonance imaging; pathophysiology; priority journal; rat; sequence analysis; Adolescent; Animals; Aromatic-L-Amino-Acid Decarboxylases; Autoantibodies; Cattle; Child; Child, Preschool; Female; Gonadotropin-Releasing Hormone; Human Growth Hormone; Humans; Male; Median Eminence; Polyendocrinopathies, Autoimmune; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase; Bovinae
Cocco, C., Meloni, A., Boi, F., Pinna, G., Possenti, R., Mariotti, S., et al. (2005). Median eminence dopaminergic nerve terminals: a novel target in autoimmune polyendocrine syndrome?. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 90(7), 4108-4111 [10.1210/jc.2004-2184].
Cocco, C; Meloni, A; Boi, F; Pinna, G; Possenti, R; Mariotti, S; Ferri, Gl
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56999
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