Energy homeostasis is a complex physiological function coordinated at multiple levels. The issue of genetic regulation of nutrition and metabolism is attracting increasing interest and new energy homeostasis-regulatory genes are continuously identified. Among these genes, vgf is gaining increasing interest following two observations: (1) VGF-/- mice have a lean and hypermetabolic phenotype; (2) the first VGF-derived peptide involved in energy homeostasis, named TLQP-21, has been identified. The aim of this review will be to discuss the role of the vgf gene and VGF derived peptides in metabolic and nutritional functions. In particular we will: (1) provide a brief overview on the central systems regulating energy homeostasis and nutrition particularly focusing on the melanocortin system; (2) introduce the structure and molecular characteristic of vgf; (3) describe the phenotype of VGF deficient mice; (4) present recent data on the metabolic role of VGF-derived peptides, particularly focusing on one peptide named TLQP-211

Bartolomucci, A., Possenti, R., Levi, A., Pavone, F., Moles, A. (2007). The role of the vgf gene and VGF-derived peptides in nutrition and metabolism. GENES & NUTRITION, 2(2), 169-180 [10.1007/s12263-007-0047-0].

The role of the vgf gene and VGF-derived peptides in nutrition and metabolism

POSSENTI, ROBERTA;
2007-01-01

Abstract

Energy homeostasis is a complex physiological function coordinated at multiple levels. The issue of genetic regulation of nutrition and metabolism is attracting increasing interest and new energy homeostasis-regulatory genes are continuously identified. Among these genes, vgf is gaining increasing interest following two observations: (1) VGF-/- mice have a lean and hypermetabolic phenotype; (2) the first VGF-derived peptide involved in energy homeostasis, named TLQP-21, has been identified. The aim of this review will be to discuss the role of the vgf gene and VGF derived peptides in metabolic and nutritional functions. In particular we will: (1) provide a brief overview on the central systems regulating energy homeostasis and nutrition particularly focusing on the melanocortin system; (2) introduce the structure and molecular characteristic of vgf; (3) describe the phenotype of VGF deficient mice; (4) present recent data on the metabolic role of VGF-derived peptides, particularly focusing on one peptide named TLQP-211
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09 - FISIOLOGIA
English
Con Impact Factor ISI
1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine; carboprost methyl; indometacin; melanocortin receptor; messenger RNA; naproxen; nerve growth factor; neuropeptide; neuropeptide Y receptor; peptide derivative; prostaglandin D2; prostaglandin E2; prostaglandin F2; protein AQEE 30; protein precursor; protein TLQP 21; protein vgf; adipose tissue; amino acid sequence; autonomic nervous system; biological activity; catabolism; energy balance; energy expenditure; energy metabolism; food intake; gene function; gene structure; genetic conservation; homeostasis; human; hypothalamus; lipid diet; metabolism; nonhuman; nutrition; perinatal period; phenotype; protein analysis; review; Mus
Bartolomucci, A., Possenti, R., Levi, A., Pavone, F., Moles, A. (2007). The role of the vgf gene and VGF-derived peptides in nutrition and metabolism. GENES & NUTRITION, 2(2), 169-180 [10.1007/s12263-007-0047-0].
Bartolomucci, A; Possenti, R; Levi, A; Pavone, F; Moles, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56995
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