Medication overuse headache (MOH) can be considered a clinical condition at the boundaries between drug addiction and chronic pain disorder. The common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met), is related with behaviour disorders and substance abuse. With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk factor for the development of the disease, we investigated whether the presence of a functional BDNF polymorphism might determine clinical differences within a group of 90 MOH patients, particularly in monthly drug consumption, that is the hallmark of disease. Directly comparing MOH patients homozygous for G allele (G/G) with carriers of A allele (non-G/G), we have observed 47 G/G genotypes and 60 non-G/G genotypes. Non-G/G had a higher consumption of monthly drug number (Cohen's d = 0.76) than G/G patients. At multiple regression analysis, the Val66Met BDNF polymorphism emerged as a significant independent predictor of analgesic drug consumption (Beta = 0.33, Cohen's f (2) = 0.134). These findings showed an influence of examined BDNF polymorphism in the MOH clinical features, supporting the idea that MOH is a substance abuse disorder.

Di Lorenzo, C., DI LORENZO, G., Sances, G., Ghiotto, N., Guaschino, E., Grieco, G., et al. (2009). Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. THE JOURNAL OF HEADACHE AND PAIN, 10(5), 349-355 [10.1007/s10194-009-0136-0].

Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism

DI LORENZO, GIORGIO;TROISI, ALFONSO;SIRACUSANO, ALBERTO;
2009-01-01

Abstract

Medication overuse headache (MOH) can be considered a clinical condition at the boundaries between drug addiction and chronic pain disorder. The common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met), is related with behaviour disorders and substance abuse. With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk factor for the development of the disease, we investigated whether the presence of a functional BDNF polymorphism might determine clinical differences within a group of 90 MOH patients, particularly in monthly drug consumption, that is the hallmark of disease. Directly comparing MOH patients homozygous for G allele (G/G) with carriers of A allele (non-G/G), we have observed 47 G/G genotypes and 60 non-G/G genotypes. Non-G/G had a higher consumption of monthly drug number (Cohen's d = 0.76) than G/G patients. At multiple regression analysis, the Val66Met BDNF polymorphism emerged as a significant independent predictor of analgesic drug consumption (Beta = 0.33, Cohen's f (2) = 0.134). These findings showed an influence of examined BDNF polymorphism in the MOH clinical features, supporting the idea that MOH is a substance abuse disorder.
2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/25 - PSICHIATRIA
English
Addictive behaviour; Brain-derived neurotrophic factor (BDNF); Genetic polymorphisms; Medication overuse headache (MOH)
Di Lorenzo, C., DI LORENZO, G., Sances, G., Ghiotto, N., Guaschino, E., Grieco, G., et al. (2009). Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. THE JOURNAL OF HEADACHE AND PAIN, 10(5), 349-355 [10.1007/s10194-009-0136-0].
Di Lorenzo, C; DI LORENZO, G; Sances, G; Ghiotto, N; Guaschino, E; Grieco, G; Santorelli, F; Casali, C; Troisi, A; Siracusano, A; Pierelli, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons Creative Commons

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56977
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 51
social impact