Nocardiosis is a rare and potentially life-threatening infection caused by several species of the Nocardia genus. Most cases occur in immunocompromised patients, and a delay in establishing the diagnosis is common due to the non-specific clinical presentations and the difficulty in cultivating Nocardia. Although the majority of pulmonary nocardiosis cases are caused by Nocardia asteroides, cases of human infection due to N. farcinica are increasingly diagnosed due to recent developments in taxonomy and diagnostic methods. N. farcinica is a separate species from N. asteroides and appears to be more virulent and resistant to antibiotics. Herein, we describe the case of a 65-year-old HIV-negative immunocompromised patient with a fulminant bilateral pulmonary nocardiosis while on empirical treatment with trimethoprim/sulfamethoxazole and imipenem. Post-mortem diagnosis of N. farcinica infection was performed by means of DNA amplification and sequencing of the 65-kDa bacterial heat shock protein. Copyright (C) 2006 S. Karger AG, Basel.

Bocchino, M., Paglia, M.g., Marruchella, A., Contini, S., Festa, A., Saltini, C. (2008). Molecular diagnosis of fatal Nocardia farcinica pneumonia in an HIV-negative patient. RESPIRATION, 75(4), 461-465 [10.1159/000094390].

Molecular diagnosis of fatal Nocardia farcinica pneumonia in an HIV-negative patient

SALTINI, CESARE
2008-01-01

Abstract

Nocardiosis is a rare and potentially life-threatening infection caused by several species of the Nocardia genus. Most cases occur in immunocompromised patients, and a delay in establishing the diagnosis is common due to the non-specific clinical presentations and the difficulty in cultivating Nocardia. Although the majority of pulmonary nocardiosis cases are caused by Nocardia asteroides, cases of human infection due to N. farcinica are increasingly diagnosed due to recent developments in taxonomy and diagnostic methods. N. farcinica is a separate species from N. asteroides and appears to be more virulent and resistant to antibiotics. Herein, we describe the case of a 65-year-old HIV-negative immunocompromised patient with a fulminant bilateral pulmonary nocardiosis while on empirical treatment with trimethoprim/sulfamethoxazole and imipenem. Post-mortem diagnosis of N. farcinica infection was performed by means of DNA amplification and sequencing of the 65-kDa bacterial heat shock protein. Copyright (C) 2006 S. Karger AG, Basel.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Con Impact Factor ISI
Molecular diagnosis; Nocardia farcinica; Pneumonia
cotrimoxazole; heat shock protein 65; imipenem; prednisone; aged; anamnesis; article; case report; clinical examination; clinical feature; computer assisted tomography; diagnostic procedure; DNA extraction; DNA sequence; female; gene amplification; hospital admission; human; Human immunodeficiency virus; human tissue; immunocompromised patient; laboratory test; lung auscultation; lung nocardiosis; Nocardia farcinica; nocardiosis; nucleotide sequence; pneumonia; polymerase chain reaction; priority journal; respiratory distress; sputum cytodiagnosis; thorax radiography; vasculitis; Aged; Fatal Outcome; Female; Heat-Shock Proteins; HIV Seronegativity; Humans; Immunocompromised Host; Nocardia; Nocardia Infections; Pneumonia, Bacterial; Polymerase Chain Reaction; Sequence Analysis, DNA
Bocchino, M., Paglia, M.g., Marruchella, A., Contini, S., Festa, A., Saltini, C. (2008). Molecular diagnosis of fatal Nocardia farcinica pneumonia in an HIV-negative patient. RESPIRATION, 75(4), 461-465 [10.1159/000094390].
Bocchino, M; Paglia, Mg; Marruchella, A; Contini, S; Festa, A; Saltini, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56966
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