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EnglishBACKGROUND. Prostate cancer is a significant public health problem in this country. Substantial data support a plausible role for androgens in the etiology of this disease. The human HSD17B3 gene encodes the testicular (or type III) 17beta-hydroxysteroid dehydrogenase enzyme, which catalyzes testosterone biosynthesis in men. METHODS. We have investigated the G289S (glycine at codon 289 replaced by serine) polymorphism at the HSD17B3 locus as a candidate single nucleotide polymorphism (SNP) for prostate cancer risk in constitutional DNA from 103 Italian prostate cancer patients and 109 Italian disease-free centenarians to assess the role of this SNP in susceptibility to prostate cancer. RESULTS. The G289S polymorphism confers a significant increase in risk for prostate cancer (odds ratio = 2.5; 95% confidence interval, 1.03-6.07) in our study population. CONCLUSION. Our data are consistent with a plausible role of the G289S SNP in prostate cancer susceptibility. Therefore, the HSD17B3 gene may be a plausible candidate gene for prostate cancer risk
Margiotti, K., Kim, E., Pearce, C.L., Spera, E., Novelli, G., & Reichardt, J. (2002). Association of the G289S single nucleotide polymorphism in the HSD17B3 gene with prostate cancer in Italian men. PROSTATE, 53(1), 65-68.
| Tipologia: | Articolo su rivista |
| Citazione: | Margiotti, K., Kim, E., Pearce, C.L., Spera, E., Novelli, G., & Reichardt, J. (2002). Association of the G289S single nucleotide polymorphism in the HSD17B3 gene with prostate cancer in Italian men. PROSTATE, 53(1), 65-68. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/24 - Urologia |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/pros.10134 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2002 |
| Titolo: | Association of the G289S single nucleotide polymorphism in the HSD17B3 gene with prostate cancer in Italian men |
| Autori: | |
| Autori: | Margiotti, K; Kim, E; Pearce, CL; Spera, E; Novelli, G; Reichardt, JKV |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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