Premature ejaculation (PE) is thought to be the most common male sexual dysfunction; however, the prevalence of lifelong (LL)-PE is relatively low. The aim of this study was to investigate the effects of on-demand vardenafil (10 mg) to modify the intravaginal ejaculatory latency time (IELT) in men with LL-PE without erectile dysfunction. Forty-two men (18-35 years) were enrolled in a 16-week, double-blind, placebo-controlled, cross-over study. Primary end point was the modification from baseline of IELT assessed by stopwatch technique; secondary end points were post-ejaculatory refractory time (PERT) and variations of scores at the Index of Premature Ejaculation questionnaire. The changes in geometric mean IELT were superior after taking vardenafil (0.6 +/- 0.3 vs 4.5 +/- 1.1 min, P < 0.01), compared with placebo (0.7 +/- 0.3 vs 0.9 +/- 1.0 min, ns). PERT dropped significantly after vardenafil (16.7 +/- 2.0 vs 4.3 +/- 0.9 min, P < 0.001), compared with placebo (15.3 +/- 2.2 vs 15.8 +/- 2.3 min). Patients who took vardenafil (vs placebo) reported significantly (P < 0.01) increased ejaculatory control (6 +/- 2 vs 16 +/- 2), improved overall sexual satisfaction (7 +/- 2 vs 15 +/- 1) and distress (4 +/- 1 vs 8 +/- 1) scores, respectively. Multiple regression analysis (r(2) = 0.86) for IELT by the number of attempts at sexual intercourse showed significant differences between the slopes of lines for placebo and vardenafil (P < 0.0001). The most common adverse events for vardenafil (vs placebo) were headache (10 vs 3%), flushing (12 vs 0%) and dyspepsia (10 vs 0%), which tended to disappear over the time. In conclusion, in our study, vardenafil increased IELT and reduced PERT in men with LL-PE. Besides, improvements in confidence, perception of ejaculatory control and overall sexual satisfaction were reported. International Journal of Impotence Research (2009) 21, 221-227; doi: 10.1038/ijir.2009.21; published online 28 May 2009
Aversa, A., Pili, M., Francomano, D., Bruzziches, R., Spera, E., La Pera, G., et al. (2009). Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 21(4), 221-227 [10.1038/ijir.2009.21].
Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation
SPERA, ENRICO;
2009-01-01
Abstract
Premature ejaculation (PE) is thought to be the most common male sexual dysfunction; however, the prevalence of lifelong (LL)-PE is relatively low. The aim of this study was to investigate the effects of on-demand vardenafil (10 mg) to modify the intravaginal ejaculatory latency time (IELT) in men with LL-PE without erectile dysfunction. Forty-two men (18-35 years) were enrolled in a 16-week, double-blind, placebo-controlled, cross-over study. Primary end point was the modification from baseline of IELT assessed by stopwatch technique; secondary end points were post-ejaculatory refractory time (PERT) and variations of scores at the Index of Premature Ejaculation questionnaire. The changes in geometric mean IELT were superior after taking vardenafil (0.6 +/- 0.3 vs 4.5 +/- 1.1 min, P < 0.01), compared with placebo (0.7 +/- 0.3 vs 0.9 +/- 1.0 min, ns). PERT dropped significantly after vardenafil (16.7 +/- 2.0 vs 4.3 +/- 0.9 min, P < 0.001), compared with placebo (15.3 +/- 2.2 vs 15.8 +/- 2.3 min). Patients who took vardenafil (vs placebo) reported significantly (P < 0.01) increased ejaculatory control (6 +/- 2 vs 16 +/- 2), improved overall sexual satisfaction (7 +/- 2 vs 15 +/- 1) and distress (4 +/- 1 vs 8 +/- 1) scores, respectively. Multiple regression analysis (r(2) = 0.86) for IELT by the number of attempts at sexual intercourse showed significant differences between the slopes of lines for placebo and vardenafil (P < 0.0001). The most common adverse events for vardenafil (vs placebo) were headache (10 vs 3%), flushing (12 vs 0%) and dyspepsia (10 vs 0%), which tended to disappear over the time. In conclusion, in our study, vardenafil increased IELT and reduced PERT in men with LL-PE. Besides, improvements in confidence, perception of ejaculatory control and overall sexual satisfaction were reported. International Journal of Impotence Research (2009) 21, 221-227; doi: 10.1038/ijir.2009.21; published online 28 May 2009I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
