Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.

Leo, R., Di Lorenzo, G., Tesauro, M., Razzini, C., Forleo, G., Chiricolo, G., et al. (2006). Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. JOURNAL OF CLINICAL PSYCHIATRY, 67(11), 1760-1766.

Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy

LEO, ROBERTO;DI LORENZO, GIORGIO;TESAURO, MANFREDI;ZANASI, MARCO;TROISI, ALFONSO;SIRACUSANO, ALBERTO;LAURO, RENATO;ROMEO, FRANCESCO
2006

Abstract

Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/25 - Psichiatria
English
Con Impact Factor ISI
Tumor Necrosis Factor-alpha; Humans; Interleukin-1beta; Pilot Projects; Depressive Disorder, Major; Serotonin Uptake Inhibitors; Citalopram; CD40 Ligand; Inflammation; Adult; Factor VIIa; Sertraline; Up-Regulation; Biological Markers; Female; Male; P-Selectin
Leo, R., Di Lorenzo, G., Tesauro, M., Razzini, C., Forleo, G., Chiricolo, G., et al. (2006). Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. JOURNAL OF CLINICAL PSYCHIATRY, 67(11), 1760-1766.
Leo, R; DI LORENZO, G; Tesauro, M; Razzini, C; Forleo, G; Chiricolo, G; Cola, C; Zanasi, M; Troisi, A; Siracusano, A; Lauro, R; Romeo, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56921
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