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EnglishChe-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC I for Rb-binding site, removing HDAC I from the Rb/E2F cell cycle-regulated promoters. We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules network that plays a crucial role modulating neuronal morphogenesis, axonal shape, and transport. In rat cerebellar granule neurons (CGNs) Che-1 partially colocalizes with Tau in the cytoplasm. Che-1 binds the amino-terminal region of Tau protein, which is not involved in microtubule interactions. Tau and Che-1 endogenous proteins coimmunoprecipitate from CGNs cellular lysates. In addition, Che-1/Tau interaction was demonstrated both in overexpressing COS-7 cells and CGNs by FRET analysis. Finally, we observed that Tau/Che-1 interaction is modulated during neuronal apoptosis. (C) 2003 Elsevier Inc. All rights reserved.
Barbato, C., Corbi, N., Canu, N., Fanciulli, M., Serafino, A., Ciotti, M., et al. (2003). Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons: Modulation during neuronal apoptosis. MOLECULAR AND CELLULAR NEUROSCIENCES, 24(4), 1038-1050.
| Tipologia: | Articolo su rivista |
| Citazione: | Barbato, C., Corbi, N., Canu, N., Fanciulli, M., Serafino, A., Ciotti, M., et al. (2003). Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons: Modulation during neuronal apoptosis. MOLECULAR AND CELLULAR NEUROSCIENCES, 24(4), 1038-1050. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/09 |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.mcn.2003.08.002 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2003 |
| Titolo: | Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons: Modulation during neuronal apoptosis |
| Autori: | |
| Autori: | Barbato, C; Corbi, N; Canu, N; Fanciulli, M; Serafino, A; Ciotti, M; Libri, V; Bruno, T; Amadoro, G; De Angelis, R; Calissano, P; Passananti, C |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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