Carotid stenosis is a common manifestation of systemic atherosclerosis. Apart from traditional risk factors, genetic determinants, such as polymorphisms of the renin angiotensin system (RAS), may be relevant in modulating the atherosclerotic process leading to carotid stenosis. In this study, we investigated the role of angiotensin-converting enzyme (ACE) I/D and -240A>T, angiotensinogen (AGT) M235T, and angiotensin type 1 receptor (AGTR1) 1166A > C polymorphisms in modulating the susceptibility to the disease.
Sticchi, E., Romagnuolo, I., Sofi, F., Pratesi, G., Pulli, R., Pratesi, C., et al. (2011). Association between polymorphisms of the renin angiotensin system and carotid stenosis, 54(2), 467-473 [10.1016/j.jvs.2011.01.039].
Association between polymorphisms of the renin angiotensin system and carotid stenosis
PRATESI, GIOVANNI;
2011-08-01
Abstract
Carotid stenosis is a common manifestation of systemic atherosclerosis. Apart from traditional risk factors, genetic determinants, such as polymorphisms of the renin angiotensin system (RAS), may be relevant in modulating the atherosclerotic process leading to carotid stenosis. In this study, we investigated the role of angiotensin-converting enzyme (ACE) I/D and -240A>T, angiotensinogen (AGT) M235T, and angiotensin type 1 receptor (AGTR1) 1166A > C polymorphisms in modulating the susceptibility to the disease.| File | Dimensione | Formato | |
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