Membranous nephropathy (MN) post allogeneic hematopoietic stem cell transplantation (HSCT) is a rare complication with few long-term outcome data. We describe the clinical course and outcome of an adult female patient who developed MN after allogeneic HSCT for follicular non-Hodgkin's lymphoma. MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse. After treatment with rituximab, we observed a progressive decrease of proteinuria and normalization of serum albumin. Seven months after treatment, she remains in remission. No adverse reactions to rituximab were observed throughout follow-up.

Vischini, G., Cudillo, L., Ferrannini, M., DI DANIELE, N., Cerretti, R., Arcese, W. (2009). Rituximab in post allogeneic hematopoietic stem cell transplantation membranous nephropathy: a case report. JN. JOURNAL OF NEPHROLOGY, 22, 160-163.

Rituximab in post allogeneic hematopoietic stem cell transplantation membranous nephropathy: a case report.

CUDILLO, LAURA;DI DANIELE, NICOLA;ARCESE, WILLIAM
2009-01-01

Abstract

Membranous nephropathy (MN) post allogeneic hematopoietic stem cell transplantation (HSCT) is a rare complication with few long-term outcome data. We describe the clinical course and outcome of an adult female patient who developed MN after allogeneic HSCT for follicular non-Hodgkin's lymphoma. MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse. After treatment with rituximab, we observed a progressive decrease of proteinuria and normalization of serum albumin. Seven months after treatment, she remains in remission. No adverse reactions to rituximab were observed throughout follow-up.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/14 - NEFROLOGIA
Settore MED/15 - MALATTIE DEL SANGUE
English
cisplatin; cyclophosphamide; cyclosporin A; cytarabine; dexamethasone; doxorubicin; methylprednisolone; navelbine; prednisone; rituximab; serum albumin; steroid; vincristine sulfate; glucocorticoid; immunologic factor; monoclonal antibody; absence of side effects; aged; albumin blood level; allogeneic hematopoietic stem cell transplantation; article; cancer combination chemotherapy; cancer regression; case report; creatinine clearance; drug dose reduction; drug substitution; drug withdrawal; female; follicular lymphoma; follow up; human; hypertensive crisis; immunosuppressive treatment; kidney function; kidney function test; membranous glomerulonephritis; multiple cycle treatment; peripheral edema; postoperative period; proteinuria; treatment response; weight gain; hematopoietic stem cell transplantation; nonhodgkin lymphoma; remission; treatment outcome; Aged; Antibodies, Monoclonal; Female; Glomerulonephritis, Membranous; Glucocorticoids; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Factors; Lymphoma, Non-Hodgkin; Methylprednisolone; Remission Induction; Treatment Outcome
Vischini, G., Cudillo, L., Ferrannini, M., DI DANIELE, N., Cerretti, R., Arcese, W. (2009). Rituximab in post allogeneic hematopoietic stem cell transplantation membranous nephropathy: a case report. JN. JOURNAL OF NEPHROLOGY, 22, 160-163.
Vischini, G; Cudillo, L; Ferrannini, M; DI DANIELE, N; Cerretti, R; Arcese, W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56598
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