OBJECTIVE - To assess the influence of autonomic neuropathy on toe blood press RESEARCH DESIGN AND METHODS - The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessed by standard cardiovascular tests and galvanic skin response, and 8 control subjects (C). None of the subjects had peripheral vascular disease (PVD) (ankle/brachial index 0.9-1.1. RESULTS - The TBP and toe/brachial index (TBI) were significantly lower in DN than in C and D (P < 0.01). The saturation index (SI), the ratio between foot venous and arterial partial pressure of oxygen (PO2), was significantly higher in DN than in C and D (P < 0.05). An inverse relationship was found between TBI and SI (r = 0.554, P = 0.001). CONCLUSIONS - The autonomic nervous system directly influences peripheral circulation. In diabetic patients without PVD, a failure of sympathetic fibers caused by autonomic neuropathy could lead to a reduction of TBP. Therefore, TBP cannot be used as an ischemic index in diabetic patients.

Uccioli, L., Monticone, G., Durola, L., Russo, F., Mormile, F., Mennuni, G., et al. (1994). Autonomic neuropathy influences great toe blood pressure. DIABETES CARE, 17(4), 284-287.

Autonomic neuropathy influences great toe blood pressure

UCCIOLI, LUIGI;RUSSO, FRANCESCO;
1994-01-01

Abstract

OBJECTIVE - To assess the influence of autonomic neuropathy on toe blood press RESEARCH DESIGN AND METHODS - The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessed by standard cardiovascular tests and galvanic skin response, and 8 control subjects (C). None of the subjects had peripheral vascular disease (PVD) (ankle/brachial index 0.9-1.1. RESULTS - The TBP and toe/brachial index (TBI) were significantly lower in DN than in C and D (P < 0.01). The saturation index (SI), the ratio between foot venous and arterial partial pressure of oxygen (PO2), was significantly higher in DN than in C and D (P < 0.05). An inverse relationship was found between TBI and SI (r = 0.554, P = 0.001). CONCLUSIONS - The autonomic nervous system directly influences peripheral circulation. In diabetic patients without PVD, a failure of sympathetic fibers caused by autonomic neuropathy could lead to a reduction of TBP. Therefore, TBP cannot be used as an ischemic index in diabetic patients.
1994
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
adult; article; autonomic neuropathy; blood pressure; clinical article; clinical trial; controlled clinical trial; controlled study; hallux; heart output; human; non insulin dependent diabetes mellitus; oxygen saturation; oxygen tension; peripheral circulation; systolic blood pressure; vascular resistance; Analysis of Variance; Ankle; Autonomic Nervous System; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Hypotension, Orthostatic; Middle Aged; Oxygen; Partial Pressure; Posture; Regression Analysis; Respiration; Systole; Thorax; Toes; Valsalva Maneuver
Uccioli, L., Monticone, G., Durola, L., Russo, F., Mormile, F., Mennuni, G., et al. (1994). Autonomic neuropathy influences great toe blood pressure. DIABETES CARE, 17(4), 284-287.
Uccioli, L; Monticone, G; Durola, L; Russo, F; Mormile, F; Mennuni, G; Menzinger, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56515
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