OBJECTIVE - To assess the influence of autonomic neuropathy on toe blood press RESEARCH DESIGN AND METHODS - The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessed by standard cardiovascular tests and galvanic skin response, and 8 control subjects (C). None of the subjects had peripheral vascular disease (PVD) (ankle/brachial index 0.9-1.1. RESULTS - The TBP and toe/brachial index (TBI) were significantly lower in DN than in C and D (P < 0.01). The saturation index (SI), the ratio between foot venous and arterial partial pressure of oxygen (PO2), was significantly higher in DN than in C and D (P < 0.05). An inverse relationship was found between TBI and SI (r = 0.554, P = 0.001). CONCLUSIONS - The autonomic nervous system directly influences peripheral circulation. In diabetic patients without PVD, a failure of sympathetic fibers caused by autonomic neuropathy could lead to a reduction of TBP. Therefore, TBP cannot be used as an ischemic index in diabetic patients.

Uccioli L., M.G. (1994). Autonomic neuropathy influences great toe blood pressure. DIABETES CARE, 17(4), 284-287.

Autonomic neuropathy influences great toe blood pressure

UCCIOLI, LUIGI;RUSSO, FRANCESCO;
1994

Abstract

OBJECTIVE - To assess the influence of autonomic neuropathy on toe blood press RESEARCH DESIGN AND METHODS - The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessed by standard cardiovascular tests and galvanic skin response, and 8 control subjects (C). None of the subjects had peripheral vascular disease (PVD) (ankle/brachial index 0.9-1.1. RESULTS - The TBP and toe/brachial index (TBI) were significantly lower in DN than in C and D (P < 0.01). The saturation index (SI), the ratio between foot venous and arterial partial pressure of oxygen (PO2), was significantly higher in DN than in C and D (P < 0.05). An inverse relationship was found between TBI and SI (r = 0.554, P = 0.001). CONCLUSIONS - The autonomic nervous system directly influences peripheral circulation. In diabetic patients without PVD, a failure of sympathetic fibers caused by autonomic neuropathy could lead to a reduction of TBP. Therefore, TBP cannot be used as an ischemic index in diabetic patients.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
adult; article; autonomic neuropathy; blood pressure; clinical article; clinical trial; controlled clinical trial; controlled study; hallux; heart output; human; non insulin dependent diabetes mellitus; oxygen saturation; oxygen tension; peripheral circulation; systolic blood pressure; vascular resistance; Analysis of Variance; Ankle; Autonomic Nervous System; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Hypotension, Orthostatic; Middle Aged; Oxygen; Partial Pressure; Posture; Regression Analysis; Respiration; Systole; Thorax; Toes; Valsalva Maneuver
Uccioli L., M.G. (1994). Autonomic neuropathy influences great toe blood pressure. DIABETES CARE, 17(4), 284-287.
Uccioli, L; Monticone, G; Durola, L; Russo, F; Mormile, F; Mennuni, G; Menzinger, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/56515
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