Objectives To assess the usefulness of a hybrid imaging system (single-photon emission computed tomography/ computed tomography, SPECT/CT) for functional anatomical mapping (FAM) using various radiotracers and the additional value of fused SPECT/CT images compared with SPECT alone. Methods Eighty-one consecutive patients studied for various clinical situations were evaluated: 10 with In-111-pentetreotide, four with I-123-meta-iodobenzylguanidine (I-123-MIBG), five with Tc-99m-labelled red blood cells, two with Tc-99m-antigranulocyte antibodies, four with Tc-99m-nanocolloids, 10 with Ga-67, seven with Tc-99m-methylene diphosphonate (Tc-99m-MDP), nine with Tc-99m-sestamibi, 21 with Tc-99m-tetrofosmin, two with Tl-201, three with Tc-99m-ethylcysteinate dimer (ECD), one with Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) and three with I-123-N-w-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropanel (FPCIT). The acquisition of both anatomical (CT) and functional (SPECT) data was performed during a single session. SPECT data were first interpreted alone and then re-evaluated with the addition of FAM. Results Transmission anatomical maps allowed for the precise anatomical localization of SPECT images in 79 of the 81 cases. SPECT/CT had a significant impact on the results in 33 (40.7%) of the 81 patients: FAM provided the correct localization of SPECT findings in 23 cases, allowed the definition of the functional significance of CT lesions in two and enabled the exclusion of disease in sites of physiological tracer uptake in eight. Conclusions SPECT/CT with this hybrid system is a feasible technique yielding co-registered dual-modality images. FAM allows a more precise interpretation of scintigraphic studies in several cases and fused images can improve the diagnostic accuracy of SPECT in various clinical situations. (C) 2004 Lippincott Williams Wilkins.

Schillaci, O., Danieli, R., Manni, C., Simonetti, G. (2004). Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation?. NUCLEAR MEDICINE COMMUNICATIONS, 25(7), 705-710 [10.1097/01.mnm.0000130240.83949.54].

Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation?

SCHILLACI, ORAZIO;MANNI, CARLA;SIMONETTI, GIOVANNI MARIA EGISTO
2004-01-01

Abstract

Objectives To assess the usefulness of a hybrid imaging system (single-photon emission computed tomography/ computed tomography, SPECT/CT) for functional anatomical mapping (FAM) using various radiotracers and the additional value of fused SPECT/CT images compared with SPECT alone. Methods Eighty-one consecutive patients studied for various clinical situations were evaluated: 10 with In-111-pentetreotide, four with I-123-meta-iodobenzylguanidine (I-123-MIBG), five with Tc-99m-labelled red blood cells, two with Tc-99m-antigranulocyte antibodies, four with Tc-99m-nanocolloids, 10 with Ga-67, seven with Tc-99m-methylene diphosphonate (Tc-99m-MDP), nine with Tc-99m-sestamibi, 21 with Tc-99m-tetrofosmin, two with Tl-201, three with Tc-99m-ethylcysteinate dimer (ECD), one with Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) and three with I-123-N-w-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropanel (FPCIT). The acquisition of both anatomical (CT) and functional (SPECT) data was performed during a single session. SPECT data were first interpreted alone and then re-evaluated with the addition of FAM. Results Transmission anatomical maps allowed for the precise anatomical localization of SPECT images in 79 of the 81 cases. SPECT/CT had a significant impact on the results in 33 (40.7%) of the 81 patients: FAM provided the correct localization of SPECT findings in 23 cases, allowed the definition of the functional significance of CT lesions in two and enabled the exclusion of disease in sites of physiological tracer uptake in eight. Conclusions SPECT/CT with this hybrid system is a feasible technique yielding co-registered dual-modality images. FAM allows a more precise interpretation of scintigraphic studies in several cases and fused images can improve the diagnostic accuracy of SPECT in various clinical situations. (C) 2004 Lippincott Williams Wilkins.
2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE
English
Con Impact Factor ISI
CT; Gamma camera; Hybrid imaging system; Imaging fusion; SPECT
(3 iodobenzyl)guanidine i 123; gallium 67; granulocyte antibody; hexamethylpropylene amine oxime technetium tc 99m; medronate technetium tc 99m; nanocoll tc 99m; pentetreotide in 111; radioisotope; technetium 99m; tetrofosmin tc 99m; tracer; adult; aged; anatomical variation; article; camera; computer assisted tomography; controlled study; data analysis; female; human; hybrid computer; image analysis; imaging system; major clinical study; male; medical assessment; patient selection; scintigraphy; single photon emission computer tomography; spectral sensitivity; statistical significance; Brain Diseases; Equipment Failure Analysis; Female; Humans; Image Enhancement; Male; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Subtraction Technique; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed
Schillaci, O., Danieli, R., Manni, C., Simonetti, G. (2004). Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation?. NUCLEAR MEDICINE COMMUNICATIONS, 25(7), 705-710 [10.1097/01.mnm.0000130240.83949.54].
Schillaci, O; Danieli, R; Manni, C; Simonetti, Gme
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56511
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