Recent developments of transplantation for the cure of paediatric leukaemias and solid tumours have led to increased interest in cord blood (CB) as an advantageous source of haematopoietic stem cells (HSC). Cord blood stem cells have unique biological properties: primitivity, a high proliferative capacity, a high level of telomerase, with a wide differentiation potential towards all haematopoietic lineages. Very recently, the wide differentiative potential of embryonic stem cells (ESC) towards a variety of tissues has led to a renewed interest into the possibility of producing tissues in vitro which are useful for replacing affected tissues and organs for the treatment of many conditions (cardiac infarction, hepatic failure, diabetes, osteoporosis). However, the use of human ES (raises ethical concern because their isolation requires the disruption of the blastocyst. Unsuspected properties of tissue stem cells to transdifferentiate towards a wide variety of different tissues have led to renewed interest in very primitive neonatal/fetal blood, which is a source of stem cells that may be more capable of producing high numbers of specialised cells for cell replacement therapies. In this paper, we review recent advances in the manipulation, banking, characterisation, differentiative potential and clinical use of neonatal/fetal stem cells.

Tocci, A., Luchetti, L., Isacchi, G., De Rossi, G., Arduini, D. (2001). Recent advances in the biology of fetal/cord blood stem cells. ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS, 13(3), 101-106.

Recent advances in the biology of fetal/cord blood stem cells

ISACCHI, GIANCARLO;ARDUINI, DOMENICO
2001-01-01

Abstract

Recent developments of transplantation for the cure of paediatric leukaemias and solid tumours have led to increased interest in cord blood (CB) as an advantageous source of haematopoietic stem cells (HSC). Cord blood stem cells have unique biological properties: primitivity, a high proliferative capacity, a high level of telomerase, with a wide differentiation potential towards all haematopoietic lineages. Very recently, the wide differentiative potential of embryonic stem cells (ESC) towards a variety of tissues has led to a renewed interest into the possibility of producing tissues in vitro which are useful for replacing affected tissues and organs for the treatment of many conditions (cardiac infarction, hepatic failure, diabetes, osteoporosis). However, the use of human ES (raises ethical concern because their isolation requires the disruption of the blastocyst. Unsuspected properties of tissue stem cells to transdifferentiate towards a wide variety of different tissues have led to renewed interest in very primitive neonatal/fetal blood, which is a source of stem cells that may be more capable of producing high numbers of specialised cells for cell replacement therapies. In this paper, we review recent advances in the manipulation, banking, characterisation, differentiative potential and clinical use of neonatal/fetal stem cells.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/05 - Patologia Clinica
English
Con Impact Factor ISI
Cord blood; Embryonic; Multipotent stem cells; Plasticity; Stem cells
telomerase; animal experiment; animal model; blastocyst; cell differentiation; cell isolation; cell lineage; cell proliferation; childhood leukemia; controlled study; developmental biology; diabetes mellitus; embryo cell; embryonal tissue; fetus blood; heart infarction; hematopoietic stem cell; human; in vitro study; liver failure; medical ethics; mouse; nonhuman; organ transplantation; osteoporosis; review; solid tumor; stem cell transplantation; tissue transplantation; umbilical cord blood
Tocci, A., Luchetti, L., Isacchi, G., De Rossi, G., Arduini, D. (2001). Recent advances in the biology of fetal/cord blood stem cells. ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS, 13(3), 101-106.
Tocci, A; Luchetti, L; Isacchi, G; De Rossi, G; Arduini, D
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/56394
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact