Extracorporeal photopheresis (ECP), originally used to treat cutaneous T-cell lymphoma, also has been applied to the therapy of transplant rejection. Our aim was to investigate the biologic response in two children who underwent kidney transplantation with ECP as prophylactic treatment. They received conventional immunosuppressive therapy and ECP immediately after transplantation: six applications over the course of 3 weeks. During a 12-month follow-up, the clinical course was favorable in both patients; renal histology was normal 6 months after transplantation. When compared with four transplanted controls, the ECP-treated patients showed lower tumor necrosis factor-a serum levels in the short-term and a marked increase of Foxp3-positive T-regulatory cells. T-regulatory cells were still higher than in the controls I year after transplantation. These preliminary results suggest. that the addition of ECP to standard immunosuppressive therapy induces a tolerogenic shift in the immune system of kidney transplanted patients and may pave the way to preventing chronic rejection.

Lamioni, A., Carsetti, R., Legato, A., Landolfo, A., Isacchi, G., Emma, F., et al. (2007). Induction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients. TRANSPLANTATION, 83(10), 1393-1396 [10.1097/01.tp.0000261635.30578.d8].

Induction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients

ISACCHI, GIANCARLO;
2007

Abstract

Extracorporeal photopheresis (ECP), originally used to treat cutaneous T-cell lymphoma, also has been applied to the therapy of transplant rejection. Our aim was to investigate the biologic response in two children who underwent kidney transplantation with ECP as prophylactic treatment. They received conventional immunosuppressive therapy and ECP immediately after transplantation: six applications over the course of 3 weeks. During a 12-month follow-up, the clinical course was favorable in both patients; renal histology was normal 6 months after transplantation. When compared with four transplanted controls, the ECP-treated patients showed lower tumor necrosis factor-a serum levels in the short-term and a marked increase of Foxp3-positive T-regulatory cells. T-regulatory cells were still higher than in the controls I year after transplantation. These preliminary results suggest. that the addition of ECP to standard immunosuppressive therapy induces a tolerogenic shift in the immune system of kidney transplanted patients and may pave the way to preventing chronic rejection.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/05 - Patologia Clinica
English
Con Impact Factor ISI
Children; Kidney transplantation; Photopheresis; Regulatory T cells
basiliximab; cyclosporin A; methoxsalen; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; prednisone; transcription factor FOXP3; tumor necrosis factor alpha; absence of side effects; adolescent; adult; article; chronic graft rejection; clinical article; clinical trial; controlled clinical trial; controlled study; course evaluation; drug dose reduction; follow up; graft recipient; human; immune response; immunological tolerance; kidney graft; kidney graft rejection; pilot study; preschool child; priority journal; protein blood level; PUVA; regulatory T lymphocyte; therapy effect; tissue section; treatment outcome; treatment response; Antigens, CD; Child; Creatinine; Humans; Kidney Diseases; Kidney Transplantation; Lymphocyte Depletion; Methoxsalen; Photopheresis; Postoperative Period; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha
Lamioni, A., Carsetti, R., Legato, A., Landolfo, A., Isacchi, G., Emma, F., et al. (2007). Induction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients. TRANSPLANTATION, 83(10), 1393-1396 [10.1097/01.tp.0000261635.30578.d8].
Lamioni, A; Carsetti, R; Legato, A; Landolfo, A; Isacchi, G; Emma, F; Bottazzo, Gf; Strologo, Ld
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/56392
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