The interactions between sleep and epilepsy are well known. A nodal point of the relationship between sleep and epilepsy is represented by pharmacological treatment. Sleep disturbances such as drowsiness are among the most frequent side effects of treatment with antiepileptic drugs, since they can deeply modify both sleep architecture and the sleep-wake cycle. Severe daytime somnolence affects patients' activities and it may facilitate the occurrence of seizures. These considerations underline the importance of antiepileptic drugs having anticonvulsant properties that do not negatively influence sleep and daytime somnolence. In this paper we review some relevant aspects of the effects of antiepileptic drugs on sleep. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Placidi, F., Scalise, A., Marciani, M.g., Romigi, A., Diomedi, M., Gigli, G.l. (2000). Effect of antiepileptic drugs on sleep. CLINICAL NEUROPHYSIOLOGY, 111(SUPPL. 2), 115-119 [10.1016/S1388-2457(00)00411-9].
Effect of antiepileptic drugs on sleep
PLACIDI, FABIO;MARCIANI, MARIA GRAZIA;DIOMEDI, MARINA;
2000-01-01
Abstract
The interactions between sleep and epilepsy are well known. A nodal point of the relationship between sleep and epilepsy is represented by pharmacological treatment. Sleep disturbances such as drowsiness are among the most frequent side effects of treatment with antiepileptic drugs, since they can deeply modify both sleep architecture and the sleep-wake cycle. Severe daytime somnolence affects patients' activities and it may facilitate the occurrence of seizures. These considerations underline the importance of antiepileptic drugs having anticonvulsant properties that do not negatively influence sleep and daytime somnolence. In this paper we review some relevant aspects of the effects of antiepileptic drugs on sleep. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
