The metabolic syndrome is characterized by metabolic and cardiovascular disorders, including obesity, hypertension, impaired glucose tolerance and dyslipidemia. Recently, metabolic syndrome has been associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Its pathophysiology seems to be largely due to insulin resistance and visceral adiposity, leading to a proinflammatory and prothrombotic milieu that potentiates atherosclerosis. Recent knowledge implies a role for fat-derived "adipokines," as pathogenic contributors or protective factors. Furthermore, low plasma levels of ghrelin, an orexigenic peptide that promotes a positive energy balance, have been associated with the presence of vascular damage in patients with metabolic syndrome.
Iantorno, M., Tesauro, M., Cardillo, C. (2006). Recent acquisitions on the pathophysiology of metabolic syndrome [Recenti progressi nelle conoscenze della patogenesi della sindrome metabolica]. RECENTI PROGRESSI IN MEDICINA, 97(6), 303-307.
Recent acquisitions on the pathophysiology of metabolic syndrome [Recenti progressi nelle conoscenze della patogenesi della sindrome metabolica]
TESAURO, MANFREDI;
2006-01-01
Abstract
The metabolic syndrome is characterized by metabolic and cardiovascular disorders, including obesity, hypertension, impaired glucose tolerance and dyslipidemia. Recently, metabolic syndrome has been associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Its pathophysiology seems to be largely due to insulin resistance and visceral adiposity, leading to a proinflammatory and prothrombotic milieu that potentiates atherosclerosis. Recent knowledge implies a role for fat-derived "adipokines," as pathogenic contributors or protective factors. Furthermore, low plasma levels of ghrelin, an orexigenic peptide that promotes a positive energy balance, have been associated with the presence of vascular damage in patients with metabolic syndrome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.