Cyclic AMP-dependent phosphorylation was measured in particulate and in cytosolic fractions of two brain dopaminergic areas, i.e., striatum and nucleus accumbens, of young (3 months) and old (24 months) rats. A reduced cAMP-stimulated 32P incorporation was observed in several protein bands in both brain areas in the aged group. In the soluble fraction the reduced phosphorylation of DARPP-32, which is specific for dopaminoceptive neurons bearing D-1 receptors, may be of particular relevance in the mechanisms of age-related changes in dopaminergic transmission.

Govoni, S., Rius, R., Battaini, F.m., Trabucchi, M.m. (1988). Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: evidence of an altered functioning of D1 dopaminoceptive neurons. JOURNAL OF GERONTOLOGY, 43(4), 93-97.

Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: evidence of an altered functioning of D1 dopaminoceptive neurons

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1988-07-01

Abstract

Cyclic AMP-dependent phosphorylation was measured in particulate and in cytosolic fractions of two brain dopaminergic areas, i.e., striatum and nucleus accumbens, of young (3 months) and old (24 months) rats. A reduced cAMP-stimulated 32P incorporation was observed in several protein bands in both brain areas in the aged group. In the soluble fraction the reduced phosphorylation of DARPP-32, which is specific for dopaminoceptive neurons bearing D-1 receptors, may be of particular relevance in the mechanisms of age-related changes in dopaminergic transmission.
lug-1988
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Corpus Striatum; Male; Nucleus Accumbens; Molecular Weight; Electrophoresis, Polyacrylamide Gel; Rats; Septal Nuclei; Animals; Receptors, Dopamine D1; Brain Chemistry; Cyclic AMP; Neurons; Rats, Inbred Strains; Receptors, Dopamine; Cytosol; Phosphorylation; Protein Kinases; Aging
Govoni, S., Rius, R., Battaini, F.m., Trabucchi, M.m. (1988). Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: evidence of an altered functioning of D1 dopaminoceptive neurons. JOURNAL OF GERONTOLOGY, 43(4), 93-97.
Govoni, S; Rius, R; Battaini, Fm; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55744
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