The interaction of various neuropeptides with calcium antagonist binding was investigated in rat hippocampus. Among the peptides examined Substance P selectively increased the binding of phenylalkylamine and dihydropyridine calcium antagonists; this action was receptor mediated. No effect was observed with Substance P in other brain areas and with neurotensin and met-enkephalin in all the areas examined. The modification in calcium antagonist binding is functionally paralleled by an area specific increase in voltage-dependent calcium uptake. These data suggest that in hippocampus Substance P may be an endogenous regulator of voltage sensitive calcium channels.

Battaini, F.m., Govoni, S., Del Vesco, R., Di Giovine, S., Trabucchi, M.m. (1987). Concomitant regulation of hippocampal calcium antagonist receptors and calcium uptake by substance P. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 144(3), 1135-1142.

Concomitant regulation of hippocampal calcium antagonist receptors and calcium uptake by substance P

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1987-05-14

Abstract

The interaction of various neuropeptides with calcium antagonist binding was investigated in rat hippocampus. Among the peptides examined Substance P selectively increased the binding of phenylalkylamine and dihydropyridine calcium antagonists; this action was receptor mediated. No effect was observed with Substance P in other brain areas and with neurotensin and met-enkephalin in all the areas examined. The modification in calcium antagonist binding is functionally paralleled by an area specific increase in voltage-dependent calcium uptake. These data suggest that in hippocampus Substance P may be an endogenous regulator of voltage sensitive calcium channels.
14-mag-1987
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Hippocampus; Calcium Channel Blockers; Corpus Striatum; Male; Receptors, Nicotinic; Calcium Channels; Rats; Animals; Calcium; Cerebral Cortex; Kinetics; Rats, Inbred Strains; Substance P
Battaini, F.m., Govoni, S., Del Vesco, R., Di Giovine, S., Trabucchi, M.m. (1987). Concomitant regulation of hippocampal calcium antagonist receptors and calcium uptake by substance P. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 144(3), 1135-1142.
Battaini, Fm; Govoni, S; Del Vesco, R; Di Giovine, S; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55733
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