Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.

Missale, C., Govoni, S., Pasinetti, G., Assini, C., Spano, P., Battaini, F.m., et al. (1986). Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system. JOURNAL OF GERONTOLOGY, 41(2), 136-139.

Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1986-03-01

Abstract

Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.
mar-1986
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Cocaine; Male; Corpus Striatum; Rats, Inbred Strains; Sodium Chloride; Rats; Brain; Animals; Dopamine; Cerebral Cortex; Aging
Missale, C., Govoni, S., Pasinetti, G., Assini, C., Spano, P., Battaini, F.m., et al. (1986). Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system. JOURNAL OF GERONTOLOGY, 41(2), 136-139.
Missale, C; Govoni, S; Pasinetti, G; Assini, C; Spano, P; Battaini, Fm; Trabucchi, Mm
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55729
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? ND
social impact