Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.
Missale, C., Govoni, S., Pasinetti, G., Assini, C., Spano, P., Battaini, F.m., et al. (1986). Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system. JOURNAL OF GERONTOLOGY, 41(2), 136-139.
Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system
BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1986-03-01
Abstract
Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.File in questo prodotto:
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