[3H]Nitrendipine ([3H]NTP) is a radiolabelled calcium antagonist which can be used to study neuronal calcium (Ca2+) channels. The interaction of Mn2+, Zn2+, Pb2+ and La3+ on [3H]NTP binding was studied in 3 brain areas particularly rich in [3H]NTP binding sites. Differences were observed in the brain regional distribution of [3H]NTP binding as well as in their sensitivity to the metal ions Pb, Mn and Zn. The binding data suggest that neuronal Ca2+ channels in different brain areas display distinct sensitivity to selected divalent cations.

Rius, R., Govoni, S., Battaini, F.m., Trabucchi, M.m. (1985). Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas. TOXICOLOGY LETTERS, 27(1-3), 103-108.

Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1985-09-01

Abstract

[3H]Nitrendipine ([3H]NTP) is a radiolabelled calcium antagonist which can be used to study neuronal calcium (Ca2+) channels. The interaction of Mn2+, Zn2+, Pb2+ and La3+ on [3H]NTP binding was studied in 3 brain areas particularly rich in [3H]NTP binding sites. Differences were observed in the brain regional distribution of [3H]NTP binding as well as in their sensitivity to the metal ions Pb, Mn and Zn. The binding data suggest that neuronal Ca2+ channels in different brain areas display distinct sensitivity to selected divalent cations.
set-1985
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Ion Channels; Male; Calcium Channel Blockers; Tritium; Nitrendipine; Nifedipine; Rats, Inbred Strains; Rats; Metals; Brain; Animals
Rius, R., Govoni, S., Battaini, F.m., Trabucchi, M.m. (1985). Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas. TOXICOLOGY LETTERS, 27(1-3), 103-108.
Rius, R; Govoni, S; Battaini, Fm; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55680
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