Calcium entry blocker (CEB) use has been proposed in a variety of neurological dysfunctions. Some of the new clinical applications suggest a direct non-vascular action on neuronal activity. This view is supported by the observation that in brain CEBs bind preferentially to neuronal terminals and not to vascular elements. The data reported indicate that CEBs modify both in vitro and in vivo neurotransmitter release using brain slices and that their binding sites display some degree of plasticity in various experimental conditions altering neuronal transmission.

Govoni, S., Battaini, F.m., Magnoni, M., Trabucchi, M.m. (1985). Non-vascular central nervous system effects of calcium entry blockers. CEPHALALGIA, 5 Suppl 2, 115-118.

Non-vascular central nervous system effects of calcium entry blockers

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1985-05-01

Abstract

Calcium entry blocker (CEB) use has been proposed in a variety of neurological dysfunctions. Some of the new clinical applications suggest a direct non-vascular action on neuronal activity. This view is supported by the observation that in brain CEBs bind preferentially to neuronal terminals and not to vascular elements. The data reported indicate that CEBs modify both in vitro and in vivo neurotransmitter release using brain slices and that their binding sites display some degree of plasticity in various experimental conditions altering neuronal transmission.
mag-1985
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Calcium Channel Blockers; Age Factors; Enkephalin, Methionine; Synaptic Membranes; Rats, Inbred Strains; Rats; Brain; Animals; Dopamine; Binding Sites; Neurotransmitter Agents
Govoni, S., Battaini, F.m., Magnoni, M., Trabucchi, M.m. (1985). Non-vascular central nervous system effects of calcium entry blockers. CEPHALALGIA, 5 Suppl 2, 115-118.
Govoni, S; Battaini, Fm; Magnoni, M; Trabucchi, Mm
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55678
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? ND
social impact