Previous studies have shown that kynurenine may have convulsant activity. In the present investigation the intracerebroventricular injection of L- but not D-kynurenine induced convulsions in the rat. In vitro, L- but not D-kynurenine was able to displace 3H-GABA from rat brain membrane preparations. The action was specific for 3H-GABA and was not observed with other ligands. The data suggest that the convulsant activity of L-kynurenine might be due to an interaction with GABA receptors.

Pinelli, A., Govoni, S., Ossi, C., Battaini, F.m., Caimi, B., Trivulzio, S. (1985). Kynurenine may directly interact with GABA receptors in rat brain. PHARMACOLOGY, 30(5), 255-258.

Kynurenine may directly interact with GABA receptors in rat brain

BATTAINI, FIORENZO MARIA;
1985-01-01

Abstract

Previous studies have shown that kynurenine may have convulsant activity. In the present investigation the intracerebroventricular injection of L- but not D-kynurenine induced convulsions in the rat. In vitro, L- but not D-kynurenine was able to displace 3H-GABA from rat brain membrane preparations. The action was specific for 3H-GABA and was not observed with other ligands. The data suggest that the convulsant activity of L-kynurenine might be due to an interaction with GABA receptors.
1985
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Membranes; Injections, Intraventricular; Tryptophan; Binding, Competitive; Rats; Animals; Brain Chemistry; Bicuculline; Kynurenine; Rats, Inbred Strains; Receptors, GABA-A; Seizures
Pinelli, A., Govoni, S., Ossi, C., Battaini, F.m., Caimi, B., Trivulzio, S. (1985). Kynurenine may directly interact with GABA receptors in rat brain. PHARMACOLOGY, 30(5), 255-258.
Pinelli, A; Govoni, S; Ossi, C; Battaini, Fm; Caimi, B; Trivulzio, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55675
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