The behavioural and neurochemical effects of caffeine were examined in rats. The intraperitoneal administration of different doses of caffeine significantly decreased DOPAC concentrations in striatum, hypothalamus and frontal cortex, but increased them in nucleus accumbens. These observations suggest that the effects of caffeine on the central nervous system (cns) are at least partially mediated through an interaction with the dopaminergic system.

Govoni, S., Petkov, V., Montefusco, O., Missale, C., Battaini, F.m., Spano, P., et al. (1984). Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures. JOURNAL OF PHARMACY AND PHARMACOLOGY, 36(7), 458-460.

Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1984-07-01

Abstract

The behavioural and neurochemical effects of caffeine were examined in rats. The intraperitoneal administration of different doses of caffeine significantly decreased DOPAC concentrations in striatum, hypothalamus and frontal cortex, but increased them in nucleus accumbens. These observations suggest that the effects of caffeine on the central nervous system (cns) are at least partially mediated through an interaction with the dopaminergic system.
lug-1984
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Phenylacetates; Male; Rats, Inbred Strains; Receptors, Dopamine; Rats; Dose-Response Relationship, Drug; Caffeine; Animals; 3,4-Dihydroxyphenylacetic Acid; Brain Chemistry
Govoni, S., Petkov, V., Montefusco, O., Missale, C., Battaini, F.m., Spano, P., et al. (1984). Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures. JOURNAL OF PHARMACY AND PHARMACOLOGY, 36(7), 458-460.
Govoni, S; Petkov, V; Montefusco, O; Missale, C; Battaini, Fm; Spano, P; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55669
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