Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's disease, amenorrhea-galactorrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.

Battaini, F.m., Govoni, S., Rius, R., Spano, P., Trabucchi, M.m. (1984). Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 16(6), 605-611.

Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1984-06-01

Abstract

Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's disease, amenorrhea-galactorrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.
giu-1984
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Dihydroergotoxine; Corpus Striatum; Antiparkinson Agents; Spiperone; Apomorphine; Tritium; Rats, Inbred Strains; Receptors, Dopamine; Rats; Animals; Butyrophenones
Battaini, F.m., Govoni, S., Rius, R., Spano, P., Trabucchi, M.m. (1984). Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 16(6), 605-611.
Battaini, Fm; Govoni, S; Rius, R; Spano, P; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55668
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