The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]Sulpiride was used as dopamine receptor ligand. A decrease of dihydroxyphenylacetic acid (DOPAC) hypothalamic concentrations and a decrease of DA receptor density in the pituitary are shown. The decreased [3H]sulpiride binding in the pituitary is consistent with the elevated serum PRL concentrations previously described in lead-exposed rats.

Govoni, S., Lucchi, L., Battaini, F.m., Spano, P., Trabucchi, M.m. (1984). Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary. TOXICOLOGY LETTERS, 20(3), 237-241.

Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1984-03-01

Abstract

The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]Sulpiride was used as dopamine receptor ligand. A decrease of dihydroxyphenylacetic acid (DOPAC) hypothalamic concentrations and a decrease of DA receptor density in the pituitary are shown. The decreased [3H]sulpiride binding in the pituitary is consistent with the elevated serum PRL concentrations previously described in lead-exposed rats.
mar-1984
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Lead Poisoning; Pituitary Gland; Hypothalamus; Rats, Inbred Strains; Receptors, Dopamine; Rats; Animals; Prolactin; 3,4-Dihydroxyphenylacetic Acid; Dopamine
Govoni, S., Lucchi, L., Battaini, F.m., Spano, P., Trabucchi, M.m. (1984). Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary. TOXICOLOGY LETTERS, 20(3), 237-241.
Govoni, S; Lucchi, L; Battaini, Fm; Spano, P; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55666
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