Human ovarian preovulatory follicular fluids (FF) from 10 women were analysed for their complement contents. Functionally active complement was detected in all the fluids studied in amounts similar to those present in normal human serum. Pooled FF was challenged by seminal plasma in order to determine whether seminal plasma could activate FF complement, the pattern of such an activation and the possible consequences on the reproductive function. FF complement activation occurred during the incubation with seminal plasma with features including alternative pathway activation, factor B and C3 conversion and reduction in total haemolytic complement, as well as an inhibition by seminal plasma of the FF complement response to a new activating challenge. Possible consequences for fertilization, implantation of a fertilized ovum and local defence mechanisms against viruses and bacteria are discussed.

Perricone, R., Pasetto, N., De Carolis, C., VAQUERO MARTIN, M.e., Piccione, E., Baschieri, L., et al. (1992). Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 89(1), 154-157.

Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma.

PERRICONE, ROBERTO;VAQUERO MARTIN, MARIA ELENA;PICCIONE, EMILIO;
1992-01-01

Abstract

Human ovarian preovulatory follicular fluids (FF) from 10 women were analysed for their complement contents. Functionally active complement was detected in all the fluids studied in amounts similar to those present in normal human serum. Pooled FF was challenged by seminal plasma in order to determine whether seminal plasma could activate FF complement, the pattern of such an activation and the possible consequences on the reproductive function. FF complement activation occurred during the incubation with seminal plasma with features including alternative pathway activation, factor B and C3 conversion and reduction in total haemolytic complement, as well as an inhibition by seminal plasma of the FF complement response to a new activating challenge. Possible consequences for fertilization, implantation of a fertilized ovum and local defence mechanisms against viruses and bacteria are discussed.
1992
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Con Impact Factor ISI
Perricone, R., Pasetto, N., De Carolis, C., VAQUERO MARTIN, M.e., Piccione, E., Baschieri, L., et al. (1992). Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 89(1), 154-157.
Perricone, R; Pasetto, N; De Carolis, C; VAQUERO MARTIN, Me; Piccione, E; Baschieri, L; Fontana, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55170
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