Over-expression of the chaperonins GroEL and GroES significantly suppressed the temperature-dependent pattern of expression of Cu,Zn superoxide dismutases in Escherichia coli and increased the yield of active enzyme. The results obtained indicate that chaperonins prevent degradation of metal-deficient enzyme molecules. GroEL was shown to form a complex with unfolded Cu,Zn superoxide dismutase in vitro, confirming that GroEL can interact with beta-stranded proteins.

Battistoni, A., Carri', M.t., Steinkuhler, C., Rotilio, G. (1993). Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli. FEBS LETTERS, 322(1), 6-9 [10.1016/0014-5793(93)81099-L].

Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli

BATTISTONI, ANDREA;CARRI', MARIA TERESA;ROTILIO, GIUSEPPE
1993-01-01

Abstract

Over-expression of the chaperonins GroEL and GroES significantly suppressed the temperature-dependent pattern of expression of Cu,Zn superoxide dismutases in Escherichia coli and increased the yield of active enzyme. The results obtained indicate that chaperonins prevent degradation of metal-deficient enzyme molecules. GroEL was shown to form a complex with unfolded Cu,Zn superoxide dismutase in vitro, confirming that GroEL can interact with beta-stranded proteins.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10
English
Con Impact Factor ISI
CU,ZN SUPEROXIDE DISMUTASE; CHAPERONIN; PROTEIN FOLDING
Battistoni, A., Carri', M.t., Steinkuhler, C., Rotilio, G. (1993). Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli. FEBS LETTERS, 322(1), 6-9 [10.1016/0014-5793(93)81099-L].
Battistoni, A; Carri', Mt; Steinkuhler, C; Rotilio, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55129
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