In our study ceftriaxone plus amikacin were employed as empirical antibiotic therapy. This antibiotic treatment allows for a once daily administration and has a broad spectrum of activity. 21 febrile episodes were treated with an antibiotic regimen of ceftriaxone 50 mg/kg/day and amikacin 30-35 mg/kg/day i.v. An earlier pilot study was carried out in which 47 febrile episodes were treated with an antibiotic regimen of ceftriaxone 80-100 mg/kg/day i.v. and amikacin 30-35 mg/kg/day i.v. in a single dose. The overall response rate was 76% (16/21) and 79% (37/47) for the pilot study. During the treatment no side effects were observed and aminoglycoside related toxicity did not occur. In conclusion, this empiric antibiotic therapy gives a high response rate and allows for a single daily administration

Cudillo, L., Masi, M., Scimo, M., Tribalto, M., Cantonetti, M., Cri scuolo, D., et al. (1989). Ceftriaxone plus amikacin in a single daily dose as empiric antibiotic therapy in granulocytopenic patients. JOURNAL OF CHEMOTHERAPY, 1(6), 413-416.

Ceftriaxone plus amikacin in a single daily dose as empiric antibiotic therapy in granulocytopenic patients

CUDILLO, LAURA;CANTONETTI, MARIA;
1989

Abstract

In our study ceftriaxone plus amikacin were employed as empirical antibiotic therapy. This antibiotic treatment allows for a once daily administration and has a broad spectrum of activity. 21 febrile episodes were treated with an antibiotic regimen of ceftriaxone 50 mg/kg/day and amikacin 30-35 mg/kg/day i.v. An earlier pilot study was carried out in which 47 febrile episodes were treated with an antibiotic regimen of ceftriaxone 80-100 mg/kg/day i.v. and amikacin 30-35 mg/kg/day i.v. in a single dose. The overall response rate was 76% (16/21) and 79% (37/47) for the pilot study. During the treatment no side effects were observed and aminoglycoside related toxicity did not occur. In conclusion, this empiric antibiotic therapy gives a high response rate and allows for a single daily administration
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/15 - Malattie del Sangue
English
Con Impact Factor ISI
amikacin; ceftriaxone; adolescent; adult; aged; article; bacterium identification; clinical article; drug efficacy; drug safety; fever; granulocytopenia; human; infection; infection prevention; intravenous drug administration; Adolescent; Adult; Aged; Agranulocytosis; Amikacin; Antibiotics, Combined; Bacterial Infections; Ceftriaxone; Human; Middle Age
Cudillo, L., Masi, M., Scimo, M., Tribalto, M., Cantonetti, M., Cri scuolo, D., et al. (1989). Ceftriaxone plus amikacin in a single daily dose as empiric antibiotic therapy in granulocytopenic patients. JOURNAL OF CHEMOTHERAPY, 1(6), 413-416.
Cudillo, L; Masi, M; Scimo, M; Tribalto, M; Cantonetti, M; Cri scuolo, D; Papa, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/55081
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