We compared the conjunctival responsiveness to histamine diphosphate in patients with vernal conjunctivitis and in healthy control subjects. Fourteen asymptomatic patients with vernal conjunctivitis and 10 healthy volunteers were challenged in one eye with 10-mu-l of increasing doses (0.01, 0.05, 0.5, and 1 mg/ml in phosphate-buffered saline) of histamine diphosphate. The contralateral eye was challenged with the diluent only. Photographs of each eye were taken for evaluation of conjunctival redness by two masked investigators. Both patients with vernal conjunctivitis and control subjects reacted to histamine with a dose-dependent conjunctival redness 2 to 5 minutes after ocular challenge. Conjunctival redness was more intense in patients with vernal conjunctivitis than in control subjects after ocular challenge with 0.01 and 0.05 mg/ml of histamine diphosphate solution (p < 0.05). Moreover, the threshold concentration of histamine diphosphate, extrapolated from each individual dose-response curve, was significantly (p < 0.02) lower in patients with vernal conjunctivitis than in control subjects. Our findings suggest that patients with vernal conjunctivitis demonstrate conjunctival hyperresponsiveness to a nonspecific challenging agent. Nonspecific conjunctival hyperreactivity, novel concept in allergic eye disease, may be relevant for a better understanding of the pathogenesis and clinical variability of vernal conjunctivitis.

Bonini, S., Bonini, S., Schiavone, M., Centofanti, M., Allansmith, M., Bucci, M. (1992). CONJUNCTIVAL HYPERRESPONSIVENESS TO OCULAR HISTAMINE CHALLENGE IN PATIENTS WITH VERNAL CONJUNCTIVITIS. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89(1), 103-107.

CONJUNCTIVAL HYPERRESPONSIVENESS TO OCULAR HISTAMINE CHALLENGE IN PATIENTS WITH VERNAL CONJUNCTIVITIS

CENTOFANTI, MARCO;
1992-01-01

Abstract

We compared the conjunctival responsiveness to histamine diphosphate in patients with vernal conjunctivitis and in healthy control subjects. Fourteen asymptomatic patients with vernal conjunctivitis and 10 healthy volunteers were challenged in one eye with 10-mu-l of increasing doses (0.01, 0.05, 0.5, and 1 mg/ml in phosphate-buffered saline) of histamine diphosphate. The contralateral eye was challenged with the diluent only. Photographs of each eye were taken for evaluation of conjunctival redness by two masked investigators. Both patients with vernal conjunctivitis and control subjects reacted to histamine with a dose-dependent conjunctival redness 2 to 5 minutes after ocular challenge. Conjunctival redness was more intense in patients with vernal conjunctivitis than in control subjects after ocular challenge with 0.01 and 0.05 mg/ml of histamine diphosphate solution (p < 0.05). Moreover, the threshold concentration of histamine diphosphate, extrapolated from each individual dose-response curve, was significantly (p < 0.02) lower in patients with vernal conjunctivitis than in control subjects. Our findings suggest that patients with vernal conjunctivitis demonstrate conjunctival hyperresponsiveness to a nonspecific challenging agent. Nonspecific conjunctival hyperreactivity, novel concept in allergic eye disease, may be relevant for a better understanding of the pathogenesis and clinical variability of vernal conjunctivitis.
1992
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - MALATTIE APPARATO VISIVO
English
Con Impact Factor ISI
VERNAL CONJUNCTIVITIS; HYPERREACTIVITY; OCULAR ALLERGY
Bonini, S., Bonini, S., Schiavone, M., Centofanti, M., Allansmith, M., Bucci, M. (1992). CONJUNCTIVAL HYPERRESPONSIVENESS TO OCULAR HISTAMINE CHALLENGE IN PATIENTS WITH VERNAL CONJUNCTIVITIS. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89(1), 103-107.
Bonini, S; Bonini, S; Schiavone, M; Centofanti, M; Allansmith, M; Bucci, M
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/54898
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