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EnglishTwo pesticides, organophosphate phosphamidon (PHO) and organochlorine dieldrin (DED) were assayed by the mouse bone marrow micronucleus test, to ascertain whether they showed genotoxic activity in vivo. Two doses, sub-lethal (PHO = 3 mg/kg b.wt.; DED = 60 mg/kg b.wt.) and lethal (PHO = 5 mg/kg b.wt.; DED = 90 mg/kg b.wt.), of each substance were administered intraperitoneally to 9-10-week old CBA male mice, in acute and repeated exposure. The sub-lethal dose was also administered at two different times and twice at 24-h intervals. Both PHO and DED proved able to induce a dose-dependent increase of micronucleated polychromatic erythrocytes (PCE). The two pesticides also showed a different detoxification time. Furthermore, the CREST staining with antikinetochore antibodies allowed us to conclude that the two chemicals are clastogens.
Cicchetti R., B.M. (1999). Induction of micronuclei in bone marrow by two pesticides and their differentiation with CREST staining: An in vivo study in mice. MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 439(2), 239-248.
| Tipologia: | Articolo su rivista |
| Citazione: | Cicchetti R., B.M. (1999). Induction of micronuclei in bone marrow by two pesticides and their differentiation with CREST staining: An in vivo study in mice. MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 439(2), 239-248. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/13 |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S1383-5718(98)00185-5 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 1999 |
| Titolo: | Induction of micronuclei in bone marrow by two pesticides and their differentiation with CREST staining: An in vivo study in mice |
| Autori: | |
| Autori: | Cicchetti R., Bari M., Argentin G. |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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