Adenosine released during myocardial ischemia is an adequate stimulus to stimulate cardiac nociceptors and to cause anginal pain. This conclusion is supported by hbe following arguments: the similarity of the adenosine-induced pain and angina pectoris with respect to quality, location and irradiation, the attenuation of adenosine-induced pain and of exercise-induced pain by adenosine receptor antagonists and the direct provocation of anginal pain by selective intracoronary infusion of adenosine. Finally, the reduction of adenosine-induced pain and of exercise-induced angina by the selective A1 adenosine receptor antagonist bamiphylline, suggests that A1 receptors are involved in the pathogenesis of adenosine-induced pain.

Iamele M., D.R. (1993). The role of adenosine in the pathogenesis of angina pectoris [RUOLO DELL'ADENOSINA NELLA PATOGENESI DEL DOLORE ANGINOSO]. CLINICA & TERAPIA CARDIOVASCOLARE, 12(4), 179-188.

The role of adenosine in the pathogenesis of angina pectoris [RUOLO DELL'ADENOSINA NELLA PATOGENESI DEL DOLORE ANGINOSO]

DOCIMO, RAFFAELLA;TOMAI, FABRIZIO;GASPARDONE, ACHILLE
1993

Abstract

Adenosine released during myocardial ischemia is an adequate stimulus to stimulate cardiac nociceptors and to cause anginal pain. This conclusion is supported by hbe following arguments: the similarity of the adenosine-induced pain and angina pectoris with respect to quality, location and irradiation, the attenuation of adenosine-induced pain and of exercise-induced pain by adenosine receptor antagonists and the direct provocation of anginal pain by selective intracoronary infusion of adenosine. Finally, the reduction of adenosine-induced pain and of exercise-induced angina by the selective A1 adenosine receptor antagonist bamiphylline, suggests that A1 receptors are involved in the pathogenesis of adenosine-induced pain.
Pubblicato
Rilevanza nazionale
Articolo
Nessuno
Settore MED/28 - Malattie Odontostomatologiche
Italian
adenosine; angina; ischemia
Iamele M., D.R. (1993). The role of adenosine in the pathogenesis of angina pectoris [RUOLO DELL'ADENOSINA NELLA PATOGENESI DEL DOLORE ANGINOSO]. CLINICA & TERAPIA CARDIOVASCOLARE, 12(4), 179-188.
Iamele, M; Docimo, R; Gioffre, G; Perino, M; Tomai, F; Gaspardone, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/54286
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