It is well known that glucocorticoids depress the natural killer (NK) activity of human peripheral blood lymphocytes when used both in vivo and in vitro. Since interferons enhance natural cytotoxicity, potential interaction between beta-interferon and hydrocortisone hemisuccinate has been investigated using mononuclear cells of peripheral blood obtained from 17 healthy donors. At the end of in vitro treatment mononuclear cells were tested for NK activity against K562 cells in a 4 h 51Cr-release assay. The results suggest that beta-interferon at the optimal treatment schedule (i.e. before and after exposure to hydrocortisone) is capable of abrogating the hydrocortisone-mediated impairment of NK function. These findings provide valuable suggestions for optimal treatment schedules with beta-interferon (i.e. beta-interferon treatment before and after exposure of effector cells to hydrocortisone) for overriding the suppressive effects of glucocorticoid therapy on natural immunity.

Fuggetta, M., Graziani, G., Aquino, A., D'Atri, S., Bonmassar, E. (1988). Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 10(6), 687-694.

Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon

GRAZIANI, GRAZIA;AQUINO, ANGELO;BONMASSAR, ENZO
1988-01-01

Abstract

It is well known that glucocorticoids depress the natural killer (NK) activity of human peripheral blood lymphocytes when used both in vivo and in vitro. Since interferons enhance natural cytotoxicity, potential interaction between beta-interferon and hydrocortisone hemisuccinate has been investigated using mononuclear cells of peripheral blood obtained from 17 healthy donors. At the end of in vitro treatment mononuclear cells were tested for NK activity against K562 cells in a 4 h 51Cr-release assay. The results suggest that beta-interferon at the optimal treatment schedule (i.e. before and after exposure to hydrocortisone) is capable of abrogating the hydrocortisone-mediated impairment of NK function. These findings provide valuable suggestions for optimal treatment schedules with beta-interferon (i.e. beta-interferon treatment before and after exposure of effector cells to hydrocortisone) for overriding the suppressive effects of glucocorticoid therapy on natural immunity.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Cytotoxicity, Immunologic; Drug Interactions; Hydrocortisone; Killer Cells, Natural; Humans; Interferon Type I; Immunosuppressive Agents
Fuggetta, M., Graziani, G., Aquino, A., D'Atri, S., Bonmassar, E. (1988). Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 10(6), 687-694.
Fuggetta, M; Graziani, G; Aquino, A; D'Atri, S; Bonmassar, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53917
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