We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D> was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D> and the degree of low signal on T1-weighted images. The quantitative information provided by <D> allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.

Castriota Scanderbeg, A., Sabatini, U., Fasano, F., Floris, R., Fraracci, L., Mario, M., et al. (2002). Diffusion of water in large demyelinating lesions: a follow-up study. NEURORADIOLOGY, 44(9), 764-767 [10.1007/s00234-002-0806-y].

Diffusion of water in large demyelinating lesions: a follow-up study

FLORIS, ROBERTO;NOCENTINI, UGO;CALTAGIRONE, CARLO
2002-09-01

Abstract

We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between and the degree of low signal on T1-weighted images. The quantitative information provided by allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.
set-2002
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Diffusion Magnetic Resonance Imaging; Multiple Sclerosis; Humans; Adult; Case-Control Studies; Brain; Middle Aged; Male; Female
Castriota Scanderbeg, A., Sabatini, U., Fasano, F., Floris, R., Fraracci, L., Mario, M., et al. (2002). Diffusion of water in large demyelinating lesions: a follow-up study. NEURORADIOLOGY, 44(9), 764-767 [10.1007/s00234-002-0806-y].
Castriota Scanderbeg, A; Sabatini, U; Fasano, F; Floris, R; Fraracci, L; Mario, M; Nocentini, U; Caltagirone, C
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53798
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