Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos dis-play an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer. This review has a double aim: the analysis of the alternatives taken by the embryo to bring into the suicidal program different cells at different stages, and the relevance of APAF1 in the onset and progression of cancer.

Cecconi F., G.P. (2001). Apaf1 in developmental apoptosis and cancer: how many ways to die?. CELLULAR AND MOLECULAR LIFE SCIENCES, 58(11), 1688-1697.

Apaf1 in developmental apoptosis and cancer: how many ways to die?

CECCONI, FRANCESCO;
2001

Abstract

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos dis-play an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer. This review has a double aim: the analysis of the alternatives taken by the embryo to bring into the suicidal program different cells at different stages, and the relevance of APAF1 in the onset and progression of cancer.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06
eng
Con Impact Factor ISI
apoptosis; brain development; carcinogenesis; embryo development; human; inner ear; limb development; malignant transformation; melanoma; mutation; nerve cell; nonhuman; review; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Brain; Ear, Inner; Embryonic and Fetal Development; Humans; Melanoma; Mitochondria; Models, Biological; Multigene Family; Neoplasms; Neurons; Phenotype; Proteins; Murinae
Cecconi F., G.P. (2001). Apaf1 in developmental apoptosis and cancer: how many ways to die?. CELLULAR AND MOLECULAR LIFE SCIENCES, 58(11), 1688-1697.
Cecconi, F; Gruss, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/53624
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