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EnglishThe human insulin receptor gene is expressed in two variant isoforms which differ by the absence (HIR-A) or presence (HIR-B) of 12 amino acids in the COOH-terminus of the extracellular alpha-subunit as a consequence of alternative splicing of exon 11. Expression of the two variant isoforms is regulated in a tissue-specific manner. In this study, we have measured the levels of the two receptor variants in isolated adipocytes from 10 non-insulin-dependent diabetes mellitus (NIDDM) and 11 normal subjects using an immunological assay, based on the ability of a human anti-receptor autoantibody to discriminate between HIR-A and HIR-B. Results indicate that levels of HIR-B variant are increased in NIDDM patients.
Sesti, G., Marini, M.A., Tullio, A.N., Montemurro, A., Borboni, P., Fusco, A., et al. (1991). Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 181(3), 1419-24.
| Tipologia: | Articolo su rivista |
| Citazione: | Sesti, G., Marini, M.A., Tullio, A.N., Montemurro, A., Borboni, P., Fusco, A., et al. (1991). Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 181(3), 1419-24. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 31-dic-1991 |
| Titolo: | Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients |
| Autori: | |
| Autori: | Sesti, G; Marini, MA; Tullio, AN; Montemurro, A; Borboni, P; Fusco, A; Accili, D; Lauro, R |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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