We have investigated the effects of interleukin 2 (IL-2) on cytotoxic activity of spleen lymphocytes, from normal and cyclophosphamide (200 mg/kg) or B-16 melanoma suppressed mice, after in vitro or in vivo pretreatment with thymosin alpha 1 (TA1). The results of this study indicate that pretreatment in vitro (100 ng/ml for 1 hr) or in vivo (200 micrograms/kg/day for 4 days) with thymosin alpha 1 (TA1), significantly increased the IL-2 (from 100 to 500 U/ml) in vitro induced cytotoxic activity of spleen lymphocytes, collected from both normal and cyclophosphamide and tumor-suppressed animals, against both YAC-1 (NK sensitive) and MBL-2 (NK resistant) cell lines. The potential use in combination of these two different biological response modifiers, useful in enhancing the immunological responses to IL-2 of lymphocytes, may provide a novel model of immunotherapeutic intervention in cancer.

Mastino, A., Favalli, C., Grelli, S., Innocenti, F., Garaci, E. (1991). Thymosin alpha 1 potentiates interleukin 2-induced cytotoxic activity in mice. CELLULAR IMMUNOLOGY, 133(1), 196-205.

Thymosin alpha 1 potentiates interleukin 2-induced cytotoxic activity in mice

MASTINO, ANTONIO;FAVALLI, CARTESIO;GRELLI, SANDRO;GARACI, ENRICO
1991-03-01

Abstract

We have investigated the effects of interleukin 2 (IL-2) on cytotoxic activity of spleen lymphocytes, from normal and cyclophosphamide (200 mg/kg) or B-16 melanoma suppressed mice, after in vitro or in vivo pretreatment with thymosin alpha 1 (TA1). The results of this study indicate that pretreatment in vitro (100 ng/ml for 1 hr) or in vivo (200 micrograms/kg/day for 4 days) with thymosin alpha 1 (TA1), significantly increased the IL-2 (from 100 to 500 U/ml) in vitro induced cytotoxic activity of spleen lymphocytes, collected from both normal and cyclophosphamide and tumor-suppressed animals, against both YAC-1 (NK sensitive) and MBL-2 (NK resistant) cell lines. The potential use in combination of these two different biological response modifiers, useful in enhancing the immunological responses to IL-2 of lymphocytes, may provide a novel model of immunotherapeutic intervention in cancer.
mar-1991
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Cytotoxicity, Immunologic; Animals; Immunity, Cellular; Interleukin-2; Thymosin; Melanoma, Experimental; Mice, Inbred C57BL; Spleen; Mice; Lymphocytes; Cyclophosphamide; Drug Synergism
Mastino, A., Favalli, C., Grelli, S., Innocenti, F., Garaci, E. (1991). Thymosin alpha 1 potentiates interleukin 2-induced cytotoxic activity in mice. CELLULAR IMMUNOLOGY, 133(1), 196-205.
Mastino, A; Favalli, C; Grelli, S; Innocenti, F; Garaci, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53211
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