To verify whether insulin levels influence PC-1 tissue content, we studied PC-1 gene expression and protein content in skeletal muscle of patients with insulinoma, a model of primary hyperinsulinemia. Data were compared with those obtained in matched insulin sensitive or resistant healthy subjects. In addition, the effect of high insulin concentration on PC-1 protein content was studied in HepG2 cells.

Frittitta, L., Sbraccia, P., Costanzo, B., Tassi, V., D'Adamo, M., Spampinato, D., et al. (2000). High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells. DIABETES/METABOLISM RESEARCH AND REVIEWS, 16(1), 26-32.

High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells

SBRACCIA, PAOLO;D'ADAMO, MONICA;
2000-01-01

Abstract

To verify whether insulin levels influence PC-1 tissue content, we studied PC-1 gene expression and protein content in skeletal muscle of patients with insulinoma, a model of primary hyperinsulinemia. Data were compared with those obtained in matched insulin sensitive or resistant healthy subjects. In addition, the effect of high insulin concentration on PC-1 protein content was studied in HepG2 cells.
2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
English
Con Impact Factor ISI
Membrane Glycoproteins; Muscle, Skeletal; Glycogen; Phosphatidylinositol 3-Kinases; Pancreatic Neoplasms; Insulin Resistance; Humans; Kinetics; Liver Neoplasms; Glucose Clamp Technique; Insulin; Phosphoric Diester Hydrolases; Carcinoma, Hepatocellular; Insulinoma; Tumor Cells, Cultured; Receptor, Insulin; Gene Expression Regulation; Phosphorylation; Pyrophosphatases; Reference Values
Frittitta, L., Sbraccia, P., Costanzo, B., Tassi, V., D'Adamo, M., Spampinato, D., et al. (2000). High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells. DIABETES/METABOLISM RESEARCH AND REVIEWS, 16(1), 26-32.
Frittitta, L; Sbraccia, P; Costanzo, B; Tassi, V; D'Adamo, M; Spampinato, D; Ercolino, T; Purrello, F; Tamburrano, G; Vigneri, R; Trischitta, V
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53200
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 15
social impact