9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated with induction of cytoprotective heat shock proteins and suggest novel strategies for treatment of influenza virus infection.

Pica, F., Palamara, A., Rossi, A., De Marco, A., Amici, C., Santoro, M. (2000). Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 44(1), 200-204.

Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication

PICA, FRANCESCA;ROSSI, ANTONELLO;AMICI, CARLA;
2000-01-01

Abstract

9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated with induction of cytoprotective heat shock proteins and suggest novel strategies for treatment of influenza virus infection.
gen-2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Virus Replication; Animals; Viral Proteins; RNA; Influenza A virus; Prostaglandin D2; DNA; Mice; Mice, Inbred BALB C; HSP70 Heat-Shock Proteins; Antiviral Agents; Male
Pica, F., Palamara, A., Rossi, A., De Marco, A., Amici, C., Santoro, M. (2000). Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 44(1), 200-204.
Pica, F; Palamara, A; Rossi, A; De Marco, A; Amici, C; Santoro, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53112
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