Monoclonal antibodies against L-carnitine have been produced and characterized, These antibodies have been found to specifically bind L-carnitine and, with different affinities, other carnitine-related compounds. No binding was observed with choline or acetylcholine. These antibodies have been used to measure L-carnitine in biological samples and serum. Data obtained demonstrate that, in biological samples, by using radiolabelled carnitine, it is possible quickly to detect small amounts of carnitine. The high specificity of the test is clearly demonstrated.
Marini, S., Fasciglione, G., Giardina, B. (1996). Production and characterization of monoclonal antibodies against L-carnitine: Radioimmunologic assays for L-carnitine determination. CLINICA CHIMICA ACTA, 249(2009/02/01 00:00:00.000), 93-108.
Production and characterization of monoclonal antibodies against L-carnitine: Radioimmunologic assays for L-carnitine determination
MARINI, STEFANO;FASCIGLIONE, GIOVANNI;
1996-01-01
Abstract
Monoclonal antibodies against L-carnitine have been produced and characterized, These antibodies have been found to specifically bind L-carnitine and, with different affinities, other carnitine-related compounds. No binding was observed with choline or acetylcholine. These antibodies have been used to measure L-carnitine in biological samples and serum. Data obtained demonstrate that, in biological samples, by using radiolabelled carnitine, it is possible quickly to detect small amounts of carnitine. The high specificity of the test is clearly demonstrated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
