Monoclonal antibodies against L-carnitine have been produced and characterized, These antibodies have been found to specifically bind L-carnitine and, with different affinities, other carnitine-related compounds. No binding was observed with choline or acetylcholine. These antibodies have been used to measure L-carnitine in biological samples and serum. Data obtained demonstrate that, in biological samples, by using radiolabelled carnitine, it is possible quickly to detect small amounts of carnitine. The high specificity of the test is clearly demonstrated.

Marini, S., Fasciglione, G., Giardina, B. (1996). Production and characterization of monoclonal antibodies against L-carnitine: Radioimmunologic assays for L-carnitine determination. CLINICA CHIMICA ACTA, 249(2009/02/01 00:00:00.000), 93-108.

Production and characterization of monoclonal antibodies against L-carnitine: Radioimmunologic assays for L-carnitine determination

MARINI, STEFANO;FASCIGLIONE, GIOVANNI;
1996-01-01

Abstract

Monoclonal antibodies against L-carnitine have been produced and characterized, These antibodies have been found to specifically bind L-carnitine and, with different affinities, other carnitine-related compounds. No binding was observed with choline or acetylcholine. These antibodies have been used to measure L-carnitine in biological samples and serum. Data obtained demonstrate that, in biological samples, by using radiolabelled carnitine, it is possible quickly to detect small amounts of carnitine. The high specificity of the test is clearly demonstrated.
1996
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
carnitine; monoclonal antibodies; radioimmunologic assays
Marini, S., Fasciglione, G., Giardina, B. (1996). Production and characterization of monoclonal antibodies against L-carnitine: Radioimmunologic assays for L-carnitine determination. CLINICA CHIMICA ACTA, 249(2009/02/01 00:00:00.000), 93-108.
Marini, S; Fasciglione, G; Giardina, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53096
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