A double-masked, randomised, placebo-controlled study was conducted to evaluate the effectiveness of nedocromil 2% eyedrops, a mast cell stabiliser, in 20 symptomatic patients with vernal conjunctivitis. A 1-week baseline period was followed by 6 weeks of treatment. Clinical examination and cytological evaluation of tear fluid were performed weekly, and the patients recorded their subjective assessment on a daily diary card. The nedocromil group showed significantly less hyperaemia in the course of treatment than did the placebo group, and significantly less itching at all visits compared with baseline itching. In the nedocromil-treated group, but not in the placebo group, the number of neutrophils, eosinophils and lymphocytes in tears decreased significantly during some treatment weeks when compared with baseline. The overall assessment of treatment efficacy by both clinician and patient was significantly in favour of nedocromil treatment over placebo.

Bonini, S., Barney, N.p., Schiavone, M., Centofanti, M., Berruto, A., Bonini, S., et al. (1992). Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis. EYE, 6(6), 648-652.

Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis

CENTOFANTI, MARCO;
1992-01-01

Abstract

A double-masked, randomised, placebo-controlled study was conducted to evaluate the effectiveness of nedocromil 2% eyedrops, a mast cell stabiliser, in 20 symptomatic patients with vernal conjunctivitis. A 1-week baseline period was followed by 6 weeks of treatment. Clinical examination and cytological evaluation of tear fluid were performed weekly, and the patients recorded their subjective assessment on a daily diary card. The nedocromil group showed significantly less hyperaemia in the course of treatment than did the placebo group, and significantly less itching at all visits compared with baseline itching. In the nedocromil-treated group, but not in the placebo group, the number of neutrophils, eosinophils and lymphocytes in tears decreased significantly during some treatment weeks when compared with baseline. The overall assessment of treatment efficacy by both clinician and patient was significantly in favour of nedocromil treatment over placebo.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - Malattie Apparato Visivo
English
Con Impact Factor ISI
nedocromil sodium; adolescent; adult; article; clinical article; clinical feature; controlled study; cytology; disease duration; drug efficacy; eosinophil; female; human; hyperemia; lacrimal fluid; leukocyte differential count; lymphocyte count; male; medical assessment; neutrophil; patient satisfaction; pruritus; school child; topical drug administration; vernal conjunctivitis; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Conjunctivitis, Allergic; Double-Blind Method; Female; Human; Hyperemia; Male; Nedocromil; Ophthalmic Solutions; Pruritus; Quinolones; Tears
Bonini, S., Barney, N.p., Schiavone, M., Centofanti, M., Berruto, A., Bonini, S., et al. (1992). Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis. EYE, 6(6), 648-652.
Bonini, S; Barney, Np; Schiavone, M; Centofanti, M; Berruto, A; Bonini, S; Allansmith, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53062
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