The aims of the following study were to compare the efficacy of Dorzolamide 1% eye drops with systemic Acetazolamide on the ocular pressure diurnal curve in patients with maximal medical therapy. Three ocular pressure curve were performed in glaucomatous patients, already receiving maximal medical therapy. After a baseline curve, patients were pretreated either with Dorzolamide 1% eye drops or 250 mg Acetazolamide tablets in a double-blind cross-over study. Dorzolamide 1% eye drops and 250 mg Acetazolamide tablets significantly reduced intraocular pressure (IOP) at 2 and 4 h after pretreatment. Both treatments caused a significantly additional decrease of IOP despite maximal medical therapy. Dorzolamide 1% eye drops is as effective as Acetazolamide tablets in reducing the IOP curve. Topical carbonic anhydrase inhibitors may represent an additional and safer treatment for those patients with uncontrolled medical glaucoma. (C) 1997 The Italian Pharmacological Society.

Centofanti, M., Manni, G.L., Napoli, D., & Bucci, M.G. (1997). Comparative effects on intraocular pressure between systemic and topical carbonic anhydrase inhibitors: A clinical masked, cross-over study. PHARMACOLOGICAL RESEARCH, 35(5), 481-485.

Comparative effects on intraocular pressure between systemic and topical carbonic anhydrase inhibitors: A clinical masked, cross-over study

CENTOFANTI, MARCO;MANNI, GIANLUCA;
1997

Abstract

The aims of the following study were to compare the efficacy of Dorzolamide 1% eye drops with systemic Acetazolamide on the ocular pressure diurnal curve in patients with maximal medical therapy. Three ocular pressure curve were performed in glaucomatous patients, already receiving maximal medical therapy. After a baseline curve, patients were pretreated either with Dorzolamide 1% eye drops or 250 mg Acetazolamide tablets in a double-blind cross-over study. Dorzolamide 1% eye drops and 250 mg Acetazolamide tablets significantly reduced intraocular pressure (IOP) at 2 and 4 h after pretreatment. Both treatments caused a significantly additional decrease of IOP despite maximal medical therapy. Dorzolamide 1% eye drops is as effective as Acetazolamide tablets in reducing the IOP curve. Topical carbonic anhydrase inhibitors may represent an additional and safer treatment for those patients with uncontrolled medical glaucoma. (C) 1997 The Italian Pharmacological Society.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - Malattie Apparato Visivo
English
Con Impact Factor ISI
glaucoma; carbonic anhydrase inhibitors; intraocular pressure
Centofanti, M., Manni, G.L., Napoli, D., & Bucci, M.G. (1997). Comparative effects on intraocular pressure between systemic and topical carbonic anhydrase inhibitors: A clinical masked, cross-over study. PHARMACOLOGICAL RESEARCH, 35(5), 481-485.
Centofanti, M; Manni, G; Napoli, D; Bucci, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/53043
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